GGA1/YDR358W Protein Information

Standard Name	Gga1p 1
Systematic Name	Ydr358wp
ORF Classification	Verified
Description	Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication (1, 2)
Name Description	Golgi-localized, Gamma-adaptin ear homology, Arf-binding protein 1

Experimental Data
Molecules/cell	656 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	557
Molecular Weight (Da)	62,319
Isoelectric Point (pI)	5.36

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gga1p (InterPro)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012B3DD \| Q06336 MIPS: YDR358W NCBI: 14548059 \| 6320565 \| 849172 \| NP_010645.1 GenBank/EMBL/DDBJ: DAA12197.1 \| U28372

Amino Acid Sequence (or in FASTA format)
1 MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN 51 SKQGATPREA VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR 101 KEFLNDLVKR FPEQPPLRYS KVQQMILEAI EEWYQTICKH ASYKDDLQYI 151 NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ LRTPSELQEE QERAQAAKLE 201 ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL NKLKRKADLF 251 NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK 301 FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS 351 VTSPSKSLQP FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID 401 LLDFDSQPGE SKTALSAYSN SIVLPNGLLN SSSNSKEITA QSQRHILNQS 451 DHLRIDYELT RESMTKLRLV IFYSNISSDP ITNFALLVAS PKGTTLSLQP 501 QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC TKGDSKEESG 551 TTSLPTI*

Amino Acid Sequence (or in FASTA format)

       1  MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN
      51  SKQGATPREA VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR
     101  KEFLNDLVKR FPEQPPLRYS KVQQMILEAI EEWYQTICKH ASYKDDLQYI
     151  NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ LRTPSELQEE QERAQAAKLE
     201  ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL NKLKRKADLF
     251  NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK
     301  FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS
     351  VTSPSKSLQP FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID
     401  LLDFDSQPGE SKTALSAYSN SIVLPNGLLN SSSNSKEITA QSQRHILNQS
     451  DHLRIDYELT RESMTKLRLV IFYSNISSDP ITNFALLVAS PKGTTLSLQP
     501  QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC TKGDSKEESG
     551  TTSLPTI*

external links for Gga1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gga1p

1)	Zhdankina O, et al. (2001) Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi. Yeast 18(1):1-18
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41