ATP22/YDR350C Protein Information

Standard Name	Atp22p 1
Systematic Name	Ydr350cp
Alias	Tcm10p 2
ORF Classification	Verified
Description	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane (1, 3)
Name Description	ATPase synthase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	684
Molecular Weight (Da)	79,755
Isoelectric Point (pI)	9.61

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atp22p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000136AAB \| P50273 MIPS: YDR350C NCBI: 1729863 \| 398366511 \| 849179 \| 929985 \| NP_010637.4 GenBank/EMBL/DDBJ: DAA12190.2 \| U28372 \| U32306

Amino Acid Sequence (or in FASTA format)
1 MLKCICRVYS QPLAQMVTSP LFKHMGSAGT YTILPITNLR HLSTKNCPLK 51 IKSNRSEPLQ FGDFERQVPC SRKSGSSKNV QKRLYELRQL KTVLSETFGV 101 TEYASFFESL RNALHINNCS ENEKKKLLYD IILHQHELYP EVARKIGFYL 151 PGEVHRWFWY HIPKSESFNH YLFLLKSDVL LFTSNYCTRF TNRLIKGTEM 201 ERQLATFQIF LHDETNIKFI MEKVLKLHTF DSLIALVNGL VKAKNFRFIK 251 VFIQALLQKL EQHCYSGKDG AKQKNLRYVK FNNTLLYYLL KSGNVELFIK 301 TFQEELKFIV SSGLLNHIDG NEHILNFPIH HYLNLLRISN RQEELFNVIS 351 CLQSSPLMKY KLFKEFLMGE LIASFQAFRD PKLVCKYLLS SYSSKASANI 401 LNALGIWGWL YHSKSTTLTA PTLARELKNK NNILPNTMRI GSPVTVPILT 451 ELYRSLLSSS SVSLESGQFK NCLLDLYYKY KSFLSEEAHK YRYWRNDTGI 501 LNVFLNYIRF QAREPRLAYN VLLDFYSQPF AKKVVLTTTL CPFSIVAYKN 551 HTLTQAELSE LLQVMHKNGV PLTFKFCSAM VMHYVKMRDE KGARSWYNKI 601 LFGGFEIRHM ALIQIIKDQG WPFPKNFDET LLTELVENNN IKEPTDSTLF 651 TDEDMFEEDG KPRFNDDDVN KCTNIIRETL KSLN*

Amino Acid Sequence (or in FASTA format)

       1  MLKCICRVYS QPLAQMVTSP LFKHMGSAGT YTILPITNLR HLSTKNCPLK
      51  IKSNRSEPLQ FGDFERQVPC SRKSGSSKNV QKRLYELRQL KTVLSETFGV
     101  TEYASFFESL RNALHINNCS ENEKKKLLYD IILHQHELYP EVARKIGFYL
     151  PGEVHRWFWY HIPKSESFNH YLFLLKSDVL LFTSNYCTRF TNRLIKGTEM
     201  ERQLATFQIF LHDETNIKFI MEKVLKLHTF DSLIALVNGL VKAKNFRFIK
     251  VFIQALLQKL EQHCYSGKDG AKQKNLRYVK FNNTLLYYLL KSGNVELFIK
     301  TFQEELKFIV SSGLLNHIDG NEHILNFPIH HYLNLLRISN RQEELFNVIS
     351  CLQSSPLMKY KLFKEFLMGE LIASFQAFRD PKLVCKYLLS SYSSKASANI
     401  LNALGIWGWL YHSKSTTLTA PTLARELKNK NNILPNTMRI GSPVTVPILT
     451  ELYRSLLSSS SVSLESGQFK NCLLDLYYKY KSFLSEEAHK YRYWRNDTGI
     501  LNVFLNYIRF QAREPRLAYN VLLDFYSQPF AKKVVLTTTL CPFSIVAYKN
     551  HTLTQAELSE LLQVMHKNGV PLTFKFCSAM VMHYVKMRDE KGARSWYNKI
     601  LFGGFEIRHM ALIQIIKDQG WPFPKNFDET LLTELVENNN IKEPTDSTLF
     651  TDEDMFEEDG KPRFNDDDVN KCTNIIRETL KSLN*

external links for Atp22p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Atp22p

1)	Helfenbein KG, et al. (2003) ATP22, a nuclear gene required for expression of the F0 sector of mitochondrial ATPase in Saccharomyces cerevisiae. J Biol Chem 278(22):19751-6
2)	Zhang Y, et al. (1997) Isolation and Characterization of a Saccharomyces Cerevisiae Gene, TCM10, Involved in Mitochondrial Biogenesis Protein Eng 10:6-8
3)	Zeng X, et al. (2007) The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase subunit 6-specific translation factor. Genetics 175(1):55-63