HXT3/YDR345C Protein Information

Standard Name	Hxt3p
Systematic Name	Ydr345cp
ORF Classification	Verified
Description	Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication (1, 2)
Name Description	HeXose Transporter

Experimental Data
Molecules/cell	37200 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	567
Molecular Weight (Da)	62,557
Isoelectric Point (pI)	7.01

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hxt3p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 16 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F8FD \| P32466 MIPS: YDR345C NCBI: 1230672 \| 171672 \| 417164 \| 6320552 \| NP_010632.1 GenBank/EMBL/DDBJ: DAA12185.1 \| L07080 \| U51032
External Classifications	TC: 2.A.1.1 [The Sugar Porter (SP) Family]

Amino Acid Sequence (or in FASTA format)
1 MNSTPDLISP QKSSENSNAD LPSNSSQVMN MPEEKGVQDD FQAEADQVLT 51 NPNTGKGAYV TVSICCVMVA FGGFVFGWDT GTISGFVAQT DFLRRFGMKH 101 KDGSYYLSKV RTGLIVSIFN IGCAIGGIIL AKLGDMYGRK MGLIVVVVIY 151 IIGIIIQIAS INKWYQYFIG RIISGLGVGG IAVLSPMLIS EVAPKEMRGT 201 LVSCYQLMIT LGIFLGYCTN FGTKNYSNSV QWRVPLGLCF AWALFMIGGM 251 TFVPESPRYL VEAGQIDEAR ASLSKVNKVA PDHPFIQQEL EVIEASVEEA 301 RAAGSASWGE LFTGKPAMFK RTMMGIMIQS LQQLTGDNYF FYYGTTVFNA 351 VGMSDSFETS IVFGVVNFFS TCCSLYTVDR FGRRNCLLYG AIGMVCCYVV 401 YASVGVTRLW PNGEGNGSSK GAGNCMIVFA CFYIFCFATT WAPIAYVVIS 451 ETFPLRVKSK AMSIATAANW LWGFLIGFFT PFITGAINFY YGYVFMGCMV 501 FAYFYVFFFV PETKGLTLEE VNDMYAEGVL PWKSASWVPT SQRGANYDAD 551 ALMHDDQPFY KKMFGKK*

Amino Acid Sequence (or in FASTA format)

       1  MNSTPDLISP QKSSENSNAD LPSNSSQVMN MPEEKGVQDD FQAEADQVLT
      51  NPNTGKGAYV TVSICCVMVA FGGFVFGWDT GTISGFVAQT DFLRRFGMKH
     101  KDGSYYLSKV RTGLIVSIFN IGCAIGGIIL AKLGDMYGRK MGLIVVVVIY
     151  IIGIIIQIAS INKWYQYFIG RIISGLGVGG IAVLSPMLIS EVAPKEMRGT
     201  LVSCYQLMIT LGIFLGYCTN FGTKNYSNSV QWRVPLGLCF AWALFMIGGM
     251  TFVPESPRYL VEAGQIDEAR ASLSKVNKVA PDHPFIQQEL EVIEASVEEA
     301  RAAGSASWGE LFTGKPAMFK RTMMGIMIQS LQQLTGDNYF FYYGTTVFNA
     351  VGMSDSFETS IVFGVVNFFS TCCSLYTVDR FGRRNCLLYG AIGMVCCYVV
     401  YASVGVTRLW PNGEGNGSSK GAGNCMIVFA CFYIFCFATT WAPIAYVVIS
     451  ETFPLRVKSK AMSIATAANW LWGFLIGFFT PFITGAINFY YGYVFMGCMV
     501  FAYFYVFFFV PETKGLTLEE VNDMYAEGVL PWKSASWVPT SQRGANYDAD
     551  ALMHDDQPFY KKMFGKK*

external links for Hxt3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Hxt3p

1)	Ozcan S and Johnston M (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63(3):554-69
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41