HXT6/YDR343C Protein Information

Standard Name	Hxt6p
Systematic Name	Ydr343cp
ORF Classification	Verified
Description	High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	HeXose Transporter

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	570
Molecular Weight (Da)	62,705
Isoelectric Point (pI)	7.7

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hxt6p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F8FC \| P39003 MIPS: YDR343C NCBI: 1230670 \| 1708367 \| 6320550 \| NP_010630.1 \| NM_001180651.1 GenBank/EMBL/DDBJ: DAA12184.1 \| U51032 \| Z31691
External Classifications	TC: 2.A.1.1 [The Sugar Porter (SP) Family]

Amino Acid Sequence (or in FASTA format)
1 MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP 51 VVEIPKRPAS AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG 101 MKHKDGTNYL SKVRTGLIVS IFNIGCAIGG IILSKLGDMY GRKVGLIVVV 151 VIYIIGIIIQ IASINKWYQY FIGRIISGLG VGGIAVLSPM LISEVSPKHL 201 RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG LCFAWALFMI 251 GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV 301 EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI 351 FKAVGLSDSF ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC 401 MVVYASVGVT RLWPNGQDQP SSKGAGNCMI VFACFYIFCF ATTWAPIPYV 451 VVSETFPLRV KSKAMSIATA ANWLWGFLIG FFTPFITGAI NFYYGYVFMG 501 CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW VPPSRRGANY 551 DAEEMAHDDK PLYKRMFSTK *

Amino Acid Sequence (or in FASTA format)

       1  MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP
      51  VVEIPKRPAS AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG
     101  MKHKDGTNYL SKVRTGLIVS IFNIGCAIGG IILSKLGDMY GRKVGLIVVV
     151  VIYIIGIIIQ IASINKWYQY FIGRIISGLG VGGIAVLSPM LISEVSPKHL
     201  RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG LCFAWALFMI
     251  GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV
     301  EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI
     351  FKAVGLSDSF ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC
     401  MVVYASVGVT RLWPNGQDQP SSKGAGNCMI VFACFYIFCF ATTWAPIPYV
     451  VVSETFPLRV KSKAMSIATA ANWLWGFLIG FFTPFITGAI NFYYGYVFMG
     501  CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW VPPSRRGANY
     551  DAEEMAHDDK PLYKRMFSTK *

external links for Hxt6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	TCDB
YOGY	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Hxt6p

1)	Ozcan S and Johnston M (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63(3):554-69
2)	Reifenberger E, et al. (1997) Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression. Eur J Biochem 245(2):324-33
3)	Liang H and Gaber RF (1996) A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6. Mol Biol Cell 7(12):1953-66
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61