SWR1/YDR334W Protein Information Help

Standard Name Swr1p
Systematic Name Ydr334wp
ORF Classification Verified
Description Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction (1, 2, 3, 4, 5)
Name Description Sick With Rat8 ts
Experimental Data
Molecules/cell 656 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,514
Molecular Weight (Da) 174,529
Isoelectric Point (pI) 6.17

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Swr1p (InterPro)
Physical Interactions There are 157 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013A81C | Q05471
MIPS: YDR334W
NCBI: 1230661 | 6136666 | 6320541 | NP_010621.1 | NM_001180642.1
GenBank/EMBL/DDBJ: AAB64770.1 | DAA12176.1 | U51032
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.12 [DNA helicase]
Amino Acid Sequence (or in FASTA format)
       1  MTTSRKSHAK DKKAGGEQDL ADLKFRYDLL TNELFHLREF VSLVDYDPTH
      51  FNDSESFQKF LRETHLSLEE RGEKFTDDVA KKGTNGDLTR RRRNLRTSTV
     101  VSSETTNEKK GDIELKLESI APLVRNKCEE LKYKLSDHSN RKSIVPQKRP
     151  IQHLKKREAA KSLKFKSERK ENPLPLHEHI AEERYDHIAK VEEPSEAFTI
     201  KCPSDDSSFE NTSEHYSDNF YFTTSSEEED IKKKRGRKKK KPRIKLVVHP
     251  PKQTITNPLH VVKPGYESLH EYIASFKSLE DDLTLEEYNK YIDEQRRLLS
     301  RLKKGIENGA LKYDKETDSL QPITSKEIKT IITYKPDPIS YFYKQQDLQI
     351  HTDHLINQGI HMSKLFRSST KARIARAKKV SQMIEQHFKH VAGAEERKAK
     401  EEERHKKSLA RFAVQAVKKR WNMAEKAYRI LRKDEEEQLK RIEGKQHLSK
     451  MLEKSTQLLE AQLNQVNDDG RSSTPSSDSN DVLSESDDDM DDELSTSSDE
     501  DEEVDADVGL ENSPASTEAT PTDESLNLIQ LKEKYGHFNG SSTVYDSRNK
     551  DEKFPTLDKH ESSSSESSVM TGEESSIYSS SENESQNEND RESDDKTPSV
     601  GLSALFGKGE ESDGDLDLDD SEDFTVNSSS VEGEELEKDQ VDNSAATFER
     651  AGDFVHTQNE NRDDIKDVEE DAETKVQEEQ LSVVDVPVPS LLRGNLRTYQ
     701  KQGLNWLASL YNNHTNGILA DEMGLGKTIQ TISLLAYLAC EKENWGPHLI
     751  VVPTSVLLNW EMEFKRFAPG FKVLTYYGSP QQRKEKRKGW NKPDAFHVCI
     801  VSYQLVVQDQ HSFKRKRWQY MVLDEAHNIK NFRSTRWQAL LNFNTQRRLL
     851  LTGTPLQNNL AELWSLLYFL MPQTVIDGKK VSGFADLDAF QQWFGRPVDK
     901  IIETGQNFGQ DKETKKTVAK LHQVLRPYLL RRLKADVEKQ MPAKYEHIVY
     951  CKLSKRQRFL YDDFMSRAQT KATLASGNFM SIVNCLMQLR KVCNHPNLFE
    1001  VRPILTSFVL EHCVASDYKD VERTLLKLFK KNNQVNRVDL DFLNLVFTLN
    1051  DKDLTSYHAE EISKLTCVKN FVEEVNKLRE TNKQLQEEFG EASFLNFQDA
    1101  NQYFKYSNKQ KLEGTVDMLN FLKMVNKLRC DRRPIFGKNL IDLLTKDRRV
    1151  KYDKSSIIDN ELIKPLQTRV LDNRKIIDTF AVLTPSAVSL DMRKLALGLN
    1201  DDSSVGENTR LKVMQNCFEV SNPLHQLQTK LTIAFPDKSL LQYDCGKLQK
    1251  LAILLQQLKD NGHRALIFTQ MTKVLDVLEQ FLNYHGYLYM RLDGATKIED
    1301  RQILTERFNT DSRITVFILS SRSGGLGINL TGADTVIFYD SDWNPAMDKQ
    1351  CQDRCHRIGQ TRDVHIYRFV SEHTIESNIL KKANQKRQLD NVVIQEGDFT
    1401  TDYFSKLSVR DLLGSELPEN ASGGDKPLIA DADVAAKDPR QLERLLAQAE
    1451  DEDDVKAANL AMREVEIDND DFDESTEKKA ANEEEENHAE LDEYEGTAHV
    1501  DEYMIRFIAN GYYY*                                      

external links for Swr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP


YeastRC Mass Spec (Seattle)


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Swr1p
1) Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76
2) Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8
3) Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
5) Garay E, et al.  (2014) High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions. PLoS Genet 10(2):e1004168
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41