IRC3/YDR332W Protein Information

Standard Name	Irc3p 1
Systematic Name	Ydr332wp
ORF Classification	Verified
Description	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion (1, 2)
Name Description	Increased Recombination Centers 1

Experimental Data
Molecules/cell	172 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	689
Molecular Weight (Da)	78,546
Isoelectric Point (pI)	9.49

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Irc3p (InterPro)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C0CC \| Q06683 MIPS: YDR332W NCBI: 398366495 \| 74676421 \| 914990 \| NP_010619.3 GenBank/EMBL/DDBJ: DAA12174.1 \| U32517
External Classifications	EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides] EC: 3.6.4.-

Amino Acid Sequence (or in FASTA format)
1 MTSTLATRLS TYSISLILQR IKIIKRCYSA PVLRDYQQDA IDACVNSIRQ 51 GTKRIGVSLA TGGGKTVIFS NLINQLRQNY FKERQGNFKS LILVHRRELA 101 LQATATLKKI FPDLKVHIEM GKYDCDIEDS DVIVASVQTL IRRLHKYDTN 151 SVNLIIIDEA HHSVANSYRS ILDHFKASTA ETKIPVIGFS ATFERADKRA 201 LSMVMDKIVY HRGILEMIDD KWLCEAKFTS VKIEADLSDV KSTADDFQLA 251 PLSSLMNTKE INEVILKTYL HKKQEKSLKS TLLFGVDKAH VQSLHKLFKD 301 NGINTDYVTS DTKQIERDNI IQKFKNGETE VLMNCGIFTE GTDMPNIDCI 351 LLCRPTKSRS LLIQMIGRGL RLHHSKDHCH IIDFIGASSV GVVSAPTLLG 401 IRSDDIEFDD ATVEDLKAIQ GEIIAKQQKI DERLRALFQT DEAAMENVTE 451 RNSVADWIHS ANSVDLTLCS FDSFRNFTQS NNSYPSGKEF DEASEAVKEM 501 ELLMNSQYPW VKFASNAWGL PLKGKNHLRI YKEKSEDKLS MVYHLKMYRQ 551 LPCFITNKYA DYVPKSIIKD ANLWNVMSKV EKIINTLNSD LEGQTMQYQA 601 ISSKYSKWRQ TVPTSKQRDF VFRKLKKVYG ESSKDFIRLS LDDVTTYVNT 651 KMTKGDASNL IFASSLAPVY PLKSLLRILE YQKRRSFIK*

Amino Acid Sequence (or in FASTA format)

       1  MTSTLATRLS TYSISLILQR IKIIKRCYSA PVLRDYQQDA IDACVNSIRQ
      51  GTKRIGVSLA TGGGKTVIFS NLINQLRQNY FKERQGNFKS LILVHRRELA
     101  LQATATLKKI FPDLKVHIEM GKYDCDIEDS DVIVASVQTL IRRLHKYDTN
     151  SVNLIIIDEA HHSVANSYRS ILDHFKASTA ETKIPVIGFS ATFERADKRA
     201  LSMVMDKIVY HRGILEMIDD KWLCEAKFTS VKIEADLSDV KSTADDFQLA
     251  PLSSLMNTKE INEVILKTYL HKKQEKSLKS TLLFGVDKAH VQSLHKLFKD
     301  NGINTDYVTS DTKQIERDNI IQKFKNGETE VLMNCGIFTE GTDMPNIDCI
     351  LLCRPTKSRS LLIQMIGRGL RLHHSKDHCH IIDFIGASSV GVVSAPTLLG
     401  IRSDDIEFDD ATVEDLKAIQ GEIIAKQQKI DERLRALFQT DEAAMENVTE
     451  RNSVADWIHS ANSVDLTLCS FDSFRNFTQS NNSYPSGKEF DEASEAVKEM
     501  ELLMNSQYPW VKFASNAWGL PLKGKNHLRI YKEKSEDKLS MVYHLKMYRQ
     551  LPCFITNKYA DYVPKSIIKD ANLWNVMSKV EKIINTLNSD LEGQTMQYQA
     601  ISSKYSKWRQ TVPTSKQRDF VFRKLKKVYG ESSKDFIRLS LDDVTTYVNT
     651  KMTKGDASNL IFASSLAPVY PLKSLLRILE YQKRRSFIK*

external links for Irc3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Irc3p

1)	Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2)	de la Cruz J, et al. (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41