RSC3/YDR303C Protein Information Help

Standard Name Rsc3p
Systematic Name Ydr303cp
ORF Classification Verified
Description Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Remodel the Structure of Chromatin 5
Experimental Data
Molecules/cell 1750 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 885
Molecular Weight (Da) 101,719
Isoelectric Point (pI) 8.02

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rsc3p (InterPro)
Physical Interactions There are 140 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053005 | Q06639
MIPS: YDR303C
NCBI: 2501738 | 398366459 | 849220 | NP_010589.3
GenBank/EMBL/DDBJ: DAA12142.1 | U28374
Amino Acid Sequence (or in FASTA format)
 
       1  MDIRGRKMKK PPACVQCRKR KIGCDRVKPI CGNCMKHNKM DCFYPDVPGQ
      51  YVPSSSSSSN TRQVANGPYL NSYYASRRVS KETAALLQKN PELASLEQIR
     101  EYNTRLQLLN AQNQLNNRSS AANATLNQQH TQYIPKSVPS LESKPVTSAN
     151  ESSTPLNWVQ GPAIFHMLTS PYTQDEIINH EMNFLKGRLL ELQEITGKKI
     201  TGVNLDLKQD SSAQMQSSHS NRNQEEFLTI KKRKLSEDGV TDGDGKPIPE
     251  SERRPHLNEF KDLDPQFLDT NKVFNVFNSA ISEEGRNRLW LLPKNINKSS
     301  IFQIQYLIER DPFLFKFFND LNILIETQFN GPLHDLVASR NSIERNSGIS
     351  QILKFPSQSI TQTLINKYLS TITETNSILP ILKPKRLLPI VEQLFPSNTI
     401  NKPNSKDFET IFQVFSVTND QLLNLGFITL CLLILFESLN STVLIPLRDD
     451  EHLQLFNVLF NYLPLLKSNL TTLRFEIEKR SMCNIETLRF ISLWKYYQFV
     501  MDTSSSSSFV IDYDEDMHMA CLLSLNHETQ NQSHILTWNF IFKNYCWRHL
     551  FLGQLPLLMS EPFTNSTPII DPLLNNDFEL IDFEVNLMKY LQSKDQQLSI
     601  DKIIQLIKLL KNKNIEVSQG CLTTPSIINN IMDSLIYRNS MLYLNFYLLL
     651  QFETLKNYAK FNEILEDFLE LSRETLFFVF SNLANIKFAG HEFTFINKSI
     701  VVLQTLVLML LALYQRSFDS SKRTNDANEI SEQTDIHSNN DNSKRIKNKN
     751  VIHLIINKIA MLLSDYTKNC KKQNKLIENL IIKIKTISKY IKNLEENKVT
     801  TSADSNYSIN NGFSGISAEQ LIKLNHELSK ISESLIKTDF YEQRKNSTVS
     851  NGVLGAAAPV DSDANSDTFG LTKENFNEVF EAIRS*

external links for Rsc3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rsc3p
1) Lorch Y, et al.  (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
2) Neely KE and Workman JL  (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Campsteijn C, et al.  (2007) Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance. PLoS Genet 3(6):e92
5) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41