HDA2/YDR295C Protein Information

Standard Name	Hda2p
Systematic Name	Ydr295cp
Alias	Plo2p
ORF Classification	Verified
Description	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance (1, 2)
Name Description	Histone DeAcetylase 1

Experimental Data
Molecules/cell	1500 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	674
Molecular Weight (Da)	77,059
Isoelectric Point (pI)	9.3

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hda2p (InterPro)
Physical Interactions	There are 149 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531D0 \| Q06629 MIPS: YDR295C NCBI: 398366441 \| 74583564 \| 849217 \| NP_010581.3 GenBank/EMBL/DDBJ: DAA12134.1 \| U28374

Amino Acid Sequence (or in FASTA format)
1 MSRKNSKKLK VYYLPVTLTQ FQKDLSEILI SLHAKSFKAS IIGEPQADAV 51 NKPSGLPAGP ETHPYPTLSQ RQLTYIFDSN IRAIANHPSL LVDHYMPRQL 101 LRMEPTESSI AGSHKFQVLN QLINSICFRD REGSPNEVIK CAIIAHSIKE 151 LDLLEGLILG KKFRTKRLSG TSLYNEKHKF PNLPTVDSTI NKDGTPNSVS 201 STSSNSNSTS YTGYSKDDYD YSVKRNLKKR KINTDDWLFL ATTKHLKHDQ 251 YLLANYDIDM IISFDPMLEV ELPALQVLRN NANKDIPIIK LLVQNSPDHY 301 LLDSEIKNSS VKSSHLSNNG HVDDSQEYEE IKSSLLYFLQ ARNAPVNNCE 351 IDYIKLVKCC LEGKDCNNIL PVLDLITLDE ASKDSSDSGF WQPQLTKLQY 401 SSTELPLWDG PLDIKTYQTE LMHRAVIRLR DIQDEYAKGT VPLYEKRLNE 451 TQRQNQLDEI KNSVGLTFKK KQEVEKSIND SEKRLKHAMT ESTKLQNKIN 501 HLLKNRQELE NFNKLPSNTI SSENHLEEGS ALADKLKEYI DKNATLFNKL 551 KELQQANAEK SKLNDELRSK YQIESSKAAE SAQTLKILQE SMKSLENEVN 601 GPLTKFSTES LKKELERLQN DFQSLKARNK FLKNYITLMN RQYDLKNKNN 651 VQVEKAAANG TRFRSTRSNT PNYT*

Amino Acid Sequence (or in FASTA format)

       1  MSRKNSKKLK VYYLPVTLTQ FQKDLSEILI SLHAKSFKAS IIGEPQADAV
      51  NKPSGLPAGP ETHPYPTLSQ RQLTYIFDSN IRAIANHPSL LVDHYMPRQL
     101  LRMEPTESSI AGSHKFQVLN QLINSICFRD REGSPNEVIK CAIIAHSIKE
     151  LDLLEGLILG KKFRTKRLSG TSLYNEKHKF PNLPTVDSTI NKDGTPNSVS
     201  STSSNSNSTS YTGYSKDDYD YSVKRNLKKR KINTDDWLFL ATTKHLKHDQ
     251  YLLANYDIDM IISFDPMLEV ELPALQVLRN NANKDIPIIK LLVQNSPDHY
     301  LLDSEIKNSS VKSSHLSNNG HVDDSQEYEE IKSSLLYFLQ ARNAPVNNCE
     351  IDYIKLVKCC LEGKDCNNIL PVLDLITLDE ASKDSSDSGF WQPQLTKLQY
     401  SSTELPLWDG PLDIKTYQTE LMHRAVIRLR DIQDEYAKGT VPLYEKRLNE
     451  TQRQNQLDEI KNSVGLTFKK KQEVEKSIND SEKRLKHAMT ESTKLQNKIN
     501  HLLKNRQELE NFNKLPSNTI SSENHLEEGS ALADKLKEYI DKNATLFNKL
     551  KELQQANAEK SKLNDELRSK YQIESSKAAE SAQTLKILQE SMKSLENEVN
     601  GPLTKFSTES LKKELERLQN DFQSLKARNK FLKNYITLMN RQYDLKNKNN
     651  VQVEKAAANG TRFRSTRSNT PNYT*

external links for Hda2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hda2p

1)	Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6
2)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41