SRP101/YDR292C Protein Information

Standard Name	Srp101p 1
Systematic Name	Ydr292cp
ORF Classification	Verified
Description	Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p (2)
Name Description	Signal Recognition Particle 1

Experimental Data
Molecules/cell	2000 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	621
Molecular Weight (Da)	69,278
Isoelectric Point (pI)	7.17

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Srp101p (InterPro)
Physical Interactions	There are 16 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000135F5B \| P32916 MIPS: YDR292C NCBI: 1230656 \| 172707 \| 2507410 \| 29726744 \| 398366427 \| NP_010578.3 GenBank/EMBL/DDBJ: DAA12131.1 \| M77274 \| U51031

Amino Acid Sequence (or in FASTA format)
1 MFDQLAVFTP QGQVLYQYNC LGKKFSEIQI NSFISQLITS PVTRKESVAN 51 ANTDGFDFNL LTINSEHKNS PSFNALFYLN KQPELYFVVT FAEQTLELNQ 101 ETQQTLALVL KLWNSLHLSE SILKNRQGQN EKNKHNYVDI LQGIEDDLKK 151 FEQYFRIKYE ESIKQDHINP DNFTKNGSVP QSHNKNTKKK LRDTKGKKQS 201 TGNVGSGRKW GRDGGMLDEM NHEDAAKLDF SSSNSHNSSQ VALDSTINKD 251 SFGDRTEGGD FLIKEIDDLL SSHKDEITSG NEAKNSGYVS TAFGFLQKHV 301 LGNKTINESD LKSVLEKLTQ QLITKNVAPE AADYLTQQVS HDLVGSKTAN 351 WTSVENTARE SLTKALTQIL TPGVSVDLLR EIQSKRSKKD EEGKCDPYVF 401 SIVGVNGVGK STNLSKLAFW LLQNNFKVLI VACDTFRSGA VEQLRVHVEN 451 LAQLMDDSHV RGSKNKRGKT GNDYVELFEA GYGGSDLVTK IAKQAIKYSR 501 DQNFDIVLMD TAGRRHNDPT LMSPLKSFAD QAKPDKIIMV GEALVGTDSV 551 QQAKNFNDAF GKGRNLDFFI ISKCDTVGEM LGTMVNMVYA TGIPILFVGV 601 GQTYTDLRTL SVKWAVNTLM S*

Amino Acid Sequence (or in FASTA format)

       1  MFDQLAVFTP QGQVLYQYNC LGKKFSEIQI NSFISQLITS PVTRKESVAN
      51  ANTDGFDFNL LTINSEHKNS PSFNALFYLN KQPELYFVVT FAEQTLELNQ
     101  ETQQTLALVL KLWNSLHLSE SILKNRQGQN EKNKHNYVDI LQGIEDDLKK
     151  FEQYFRIKYE ESIKQDHINP DNFTKNGSVP QSHNKNTKKK LRDTKGKKQS
     201  TGNVGSGRKW GRDGGMLDEM NHEDAAKLDF SSSNSHNSSQ VALDSTINKD
     251  SFGDRTEGGD FLIKEIDDLL SSHKDEITSG NEAKNSGYVS TAFGFLQKHV
     301  LGNKTINESD LKSVLEKLTQ QLITKNVAPE AADYLTQQVS HDLVGSKTAN
     351  WTSVENTARE SLTKALTQIL TPGVSVDLLR EIQSKRSKKD EEGKCDPYVF
     401  SIVGVNGVGK STNLSKLAFW LLQNNFKVLI VACDTFRSGA VEQLRVHVEN
     451  LAQLMDDSHV RGSKNKRGKT GNDYVELFEA GYGGSDLVTK IAKQAIKYSR
     501  DQNFDIVLMD TAGRRHNDPT LMSPLKSFAD QAKPDKIIMV GEALVGTDSV
     551  QQAKNFNDAF GKGRNLDFFI ISKCDTVGEM LGTMVNMVYA TGIPILFVGV
     601  GQTYTDLRTL SVKWAVNTLM S*

external links for Srp101p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Srp101p

1)	Ogg SC, et al. (1992) Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae. Mol Biol Cell 3(8):895-911
2)	Ogg SC, et al. (1998) A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. J Cell Biol 142(2):341-54
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41