CCC2/YDR270W Protein Information Help

Standard Name Ccc2p
Systematic Name Ydr270wp
ORF Classification Verified
Description Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism (1, 2, 3, 4)
Name Description Cross-Complements Ca(2+) phenotype of csg1 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,004
Molecular Weight (Da) 109,828
Isoelectric Point (pI) 4.89

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ccc2p (InterPro)
Transmembrane Domains There are 8 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012663A | P38995
MIPS: YDR270W
NCBI: 114794063 | 1230642 | 13787072 | 253722853 | 538515 | 6320475 | 728935 | NP_010556.1
GenBank/EMBL/DDBJ: DAA12113.1 | L36317 | U51030
External Classifications EC: 3.6.3.4 [Copper-exporting ATPase]
Amino Acid Sequence (or in FASTA format)
 
       1  MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV
      51  TADSIKEIIE DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK
     101  QVEGIEGVES VVVSLVTEEC HVIYEPSKTT LETAREMIED CGFDSNIIMD
     151  GNGNADMTEK TVILKVTKAF EDESPLILSS VSERFQFLLD LGVKSIEISD
     201  DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT QLRLLSKEDE
     251  IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF
     301  YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF
     351  SVFSLVHNMF HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA
     401  LSKLIQLTPS VCSIISDVER NETKEIPIEL LQVNDIVEIK PGMKIPADGI
     451  ITRGESEIDE SLMTGESILV PKKTGFPVIA GSVNGPGHFY FRTTTVGEET
     501  KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL TFFIWCFILN
     551  ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG
     601  VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG
     651  NVDEDEVLAC IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL
     701  GKGIVSKCQV NGNTYDICIG NEALILEDAL KKSGFINSNV DQGNTVSYVS
     751  VNGHVFGLFE INDEVKHDSY ATVQYLQRNG YETYMITGDN NSAAKRVARE
     801  VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI NDAPALALSD
     851  LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL
     901  NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML
     951  KKWTPPDIES HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN
    1001  EEVL*

external links for Ccc2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ccc2p
1) Yuan DS, et al.  (1995) The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci U S A 92(7):2632-6
2) Fu D, et al.  (1995) Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily. Yeast 11(3):283-92
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4) Sasvari Z, et al.  (2013) The GEF1 proton-chloride exchanger affects tombusvirus replication via regulation of copper metabolism in yeast. J Virol 87(3):1800-10