YAP6/YDR259C Protein Information

Standard Name	Yap6p 1
Systematic Name	Ydr259cp
Alias	Hal7p 2
ORF Classification	Verified
Description	Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Yeast homolog of AP-1 1

Experimental Data
Molecules/cell	1350 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	383
Molecular Weight (Da)	43,597
Isoelectric Point (pI)	9.36

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yap6p (InterPro)
Physical Interactions	There are 49 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C36 \| Q03935 MIPS: YDR259C NCBI: 1136214 \| 1136215 \| 1226035 \| 398366301 \| 45269471 \| 45477263 \| NP_010545.3 GenBank/EMBL/DDBJ: DAA12099.1 \| AY557790 \| Z68329 \| Z70202

Amino Acid Sequence (or in FASTA format)
1 MQNPPLIRPD MYNQGSSSMA TYNASEKNLN EHPSPQIAQP STSQKLPYRI 51 NPTTTNGDTD ISVNSNPIQP PLPNLMHLSG PSDYRSMHQS PIHPSYIIPP 101 HSNERKQSAS YNRPQNAHVS IQPSVVFPPK SYSISYAPYQ INPPLPNGLP 151 NQSISLNKEY IAEEQLSTLP SRNTSVTTAP PSFQNSADTA KNSADNNDNN 201 DNVTKPVPDK DTQLISSSGK TLRNTRRAAQ NRTAQKAFRQ RKEKYIKNLE 251 QKSKIFDDLL AENNNFKSLN DSLRNDNNIL IAQHEAIRNA ITMLRSEYDV 301 LCNENNMLKN ENSIIKNEHN MSRNENENLK LENKRFHAEY IRMIEDIENT 351 KRKEQEQRDE IEQLKKKIRS LEEIVGRHSD SAT*

Amino Acid Sequence (or in FASTA format)

       1  MQNPPLIRPD MYNQGSSSMA TYNASEKNLN EHPSPQIAQP STSQKLPYRI
      51  NPTTTNGDTD ISVNSNPIQP PLPNLMHLSG PSDYRSMHQS PIHPSYIIPP
     101  HSNERKQSAS YNRPQNAHVS IQPSVVFPPK SYSISYAPYQ INPPLPNGLP
     151  NQSISLNKEY IAEEQLSTLP SRNTSVTTAP PSFQNSADTA KNSADNNDNN
     201  DNVTKPVPDK DTQLISSSGK TLRNTRRAAQ NRTAQKAFRQ RKEKYIKNLE
     251  QKSKIFDDLL AENNNFKSLN DSLRNDNNIL IAQHEAIRNA ITMLRSEYDV
     301  LCNENNMLKN ENSIIKNEHN MSRNENENLK LENKRFHAEY IRMIEDIENT
     351  KRKEQEQRDE IEQLKKKIRS LEEIVGRHSD SAT*

external links for Yap6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Yap6p

1)	Fernandes L, et al. (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
2)	Mendizabal I, et al. (1998) Yeast putative transcription factors involved in salt tolerance. FEBS Lett 425(2):323-8
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ward LD and Bussemaker HJ (2008) Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences. Bioinformatics 24(13):i165-71
5)	Hanlon SE, et al. (2011) The Stress Response Factors Yap6, Cin5, Phd1, and Skn7 Direct Targeting of the Conserved Co-Repressor Tup1-Ssn6 in S. cerevisiae. PLoS One 6(4):e19060
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41