BTT1/YDR252W Protein Information Help

Standard Name Btt1p 1
Systematic Name Ydr252wp
ORF Classification Verified
Description Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description BTf Three 1
Experimental Data
Molecules/cell 1820 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 149
Molecular Weight (Da) 16,620
Isoelectric Point (pI) 9.2

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Btt1p (InterPro)
Physical Interactions There are 29 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000126B1A | P40314
MIPS: YDR252W
NCBI: 1136207 | 1226028 | 45269343 | 515926 | 6320458 | 728988 | NP_010538.1 | NM_001180560.1
GenBank/EMBL/DDBJ: DAA12092.1 | AY557726 | X78724 | Z68329 | Z70202
Amino Acid Sequence (or in FASTA format)
 
       1  MPVDQEKLAK LHKLSAANKV GGTRRKINKK GNLYNNNDKD NTKLQAELHK
      51  LHPMTIENVA EANFFKKNGK VLHFNSAVVQ IAPQCNLTMI HGQPKENTLN
     101  GLYPSVASQL GSQELEYLTG LAHNLENEQT VLDQLGDRCS ETKQQVMNS*

external links for Btt1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Btt1p
1) Hu GZ and Ronne H  (1994) Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo. Nucleic Acids Res 22(14):2740-3
2) Reimann B, et al.  (1999) Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast 15(5):397-407
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Cui Y, et al.  (2008) Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes. Mol Genet Genomics 279(4):323-37
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41