PRP42/YDR235W Protein Information

Standard Name	Prp42p
Systematic Name	Ydr235wp
Alias	Mud16p , Snu65p
ORF Classification	Verified
Description	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats (1)
Name Description	Pre-mRNA Processing

Experimental Data
Molecules/cell	1730 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	544
Molecular Weight (Da)	65,145
Isoelectric Point (pI)	8.08

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Prp42p (InterPro)
Physical Interactions	There are 62 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000530EF \| Q03776 MIPS: YDR235W NCBI: 2444426 \| 6320441 \| 74627182 \| 817821 \| NP_010521.1 GenBank/EMBL/DDBJ: DAA12076.1 \| AF020682 \| Z49701

Amino Acid Sequence (or in FASTA format)
1 MDKYTALIHD ENFSTLTLNV SRYPKSLAYW EKLLNYIVKA SAPICKSTEP 51 QLLKLIRCTY SSMLNEFPYL ENYYIDFALL EYKLGNVSMS HKIFQRGLQA 101 FNQRSLLLWT SYLKFCNNVI SHQKQLFKKY ETAEEYVGLH FFSGEFWDLY 151 LEQISSRCTS SKKYWNVLRK ILEIPLHSFS KFYALWLQRI DDIMDLKQLS 201 QLTSKDELLK KLKIDINYSG RKGPYLQDAK KKLKKITKEM YMVVQYQVLE 251 IYSIFESKIY INYYTSPETL VSSDEIETWI KYLDYTITLQ TDSLTHLNFQ 301 RALLPLAHYD LVWIKYSKWL INSKNDLLGA KNVLLMGLKF SLKKTEIIKL 351 LYSVICKLNE YVLLRNLLEK IESSYSDNVE NVDDFEIFWD YLQFKTFCQN 401 SLYSSRYSDS QSNGLLNKEL FDKVWKRLSC KEKKSGQEIL LNNLVQFYSK 451 DTVEFVEKNI FQKIIEFGWE YYLQNGMFWN CYCRLIYFDT SRSYLDKRQY 501 IVRKIWPQID KKFAQSVLPS LTEFCESYFP EEMDTLEEMF TEEP*

Amino Acid Sequence (or in FASTA format)

       1  MDKYTALIHD ENFSTLTLNV SRYPKSLAYW EKLLNYIVKA SAPICKSTEP
      51  QLLKLIRCTY SSMLNEFPYL ENYYIDFALL EYKLGNVSMS HKIFQRGLQA
     101  FNQRSLLLWT SYLKFCNNVI SHQKQLFKKY ETAEEYVGLH FFSGEFWDLY
     151  LEQISSRCTS SKKYWNVLRK ILEIPLHSFS KFYALWLQRI DDIMDLKQLS
     201  QLTSKDELLK KLKIDINYSG RKGPYLQDAK KKLKKITKEM YMVVQYQVLE
     251  IYSIFESKIY INYYTSPETL VSSDEIETWI KYLDYTITLQ TDSLTHLNFQ
     301  RALLPLAHYD LVWIKYSKWL INSKNDLLGA KNVLLMGLKF SLKKTEIIKL
     351  LYSVICKLNE YVLLRNLLEK IESSYSDNVE NVDDFEIFWD YLQFKTFCQN
     401  SLYSSRYSDS QSNGLLNKEL FDKVWKRLSC KEKKSGQEIL LNNLVQFYSK
     451  DTVEFVEKNI FQKIIEFGWE YYLQNGMFWN CYCRLIYFDT SRSYLDKRQY
     501  IVRKIWPQID KKFAQSVLPS LTEFCESYFP EEMDTLEEMF TEEP*

external links for Prp42p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Prp42p

1)	Gottschalk A, et al. (1998) A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA 4(4):374-93
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41