LYS4/YDR234W Protein Information

Standard Name	Lys4p
Systematic Name	Ydr234wp
Alias	Lys3p
ORF Classification	Verified
Description	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway (1)
Name Description	LYSine requiring

Experimental Data
Molecules/cell	7350 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	693
Molecular Weight (Da)	75,150
Isoelectric Point (pI)	7.36

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Lys4p (InterPro)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EA97 \| P49367 MIPS: YDR234W NCBI: 1089840 \| 1197581 \| 1346476 \| 398366213 \| 51830249 \| 728689 \| 817820 \| NP_010520.3 GenBank/EMBL/DDBJ: DAA12075.1 \| AY723781 \| U46154 \| X93502 \| Z48612 \| Z49701
External Classifications	EC: 4.2.1.36 [Homoaconitate hydratase]

Amino Acid Sequence (or in FASTA format)
1 MLRSTTFTRS FHSSRAWLKG QNLTEKIVQS YAVNLPEGKV VHSGDYVSIK 51 PAHCMSHDNS WPVALKFMGL GATKIKNPSQ IVTTLDHDIQ NKSEKNLTKY 101 KNIENFAKKH HIDHYPAGRG IGHQIMIEEG YAFPLNMTVA SDSHSNTYGG 151 LGSLGTPIVR TDAAAIWATG QTWWQIPPVA QVELKGQLPQ GVSGKDIIVA 201 LCGLFNNDQV LNHAIEFTGD SLNALPIDHR LTIANMTTEW GALSGLFPVD 251 KTLIDWYKNR LQKLGTNNHP RINPKTIRAL EEKAKIPKAD KDAHYAKKLI 301 IDLATLTHYV SGPNSVKVSN TVQDLSQQDI KINKAYLVSC TNSRLSDLQS 351 AADVVCPTGD LNKVNKVAPG VEFYVAAASS EIEADARKSG AWEKLLKAGC 401 IPLPSGCGPC IGLGAGLLEP GEVGISATNR NFKGRMGSKD ALAYLASPAV 451 VAASAVLGKI SSPAEVLSTS EIPFSGVKTE IIENPVVEEE VNAQTEAPKQ 501 SVEILEGFPR EFSGELVLCD ADNINTDGIY PGKYTYQDDV PKEKMAQVCM 551 ENYDAEFRTK VHPGDIVVSG FNFGTGSSRE QAATALLAKG INLVVSGSFG 601 NIFSRNSINN ALLTLEIPAL IKKLREKYQG APKELTRRTG WFLKWDVADA 651 KVVVTEGSLD GPVILEQKVG ELGKNLQEII VKGGLEGWVK SQL*

Amino Acid Sequence (or in FASTA format)

       1  MLRSTTFTRS FHSSRAWLKG QNLTEKIVQS YAVNLPEGKV VHSGDYVSIK
      51  PAHCMSHDNS WPVALKFMGL GATKIKNPSQ IVTTLDHDIQ NKSEKNLTKY
     101  KNIENFAKKH HIDHYPAGRG IGHQIMIEEG YAFPLNMTVA SDSHSNTYGG
     151  LGSLGTPIVR TDAAAIWATG QTWWQIPPVA QVELKGQLPQ GVSGKDIIVA
     201  LCGLFNNDQV LNHAIEFTGD SLNALPIDHR LTIANMTTEW GALSGLFPVD
     251  KTLIDWYKNR LQKLGTNNHP RINPKTIRAL EEKAKIPKAD KDAHYAKKLI
     301  IDLATLTHYV SGPNSVKVSN TVQDLSQQDI KINKAYLVSC TNSRLSDLQS
     351  AADVVCPTGD LNKVNKVAPG VEFYVAAASS EIEADARKSG AWEKLLKAGC
     401  IPLPSGCGPC IGLGAGLLEP GEVGISATNR NFKGRMGSKD ALAYLASPAV
     451  VAASAVLGKI SSPAEVLSTS EIPFSGVKTE IIENPVVEEE VNAQTEAPKQ
     501  SVEILEGFPR EFSGELVLCD ADNINTDGIY PGKYTYQDDV PKEKMAQVCM
     551  ENYDAEFRTK VHPGDIVVSG FNFGTGSSRE QAATALLAKG INLVVSGSFG
     601  NIFSRNSINN ALLTLEIPAL IKKLREKYQG APKELTRRTG WFLKWDVADA
     651  KVVVTEGSLD GPVILEQKVG ELGKNLQEII VKGGLEGWVK SQL*

external links for Lys4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Lys4p

1)	Maragoudakis ME and Strassman M (1966) Homocitric acid accumulation by a lysine-requiring yeast mutant. J Biol Chem 241(3):695-9
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41