ADK1/YDR226W Protein Information

Standard Name	Adk1p 1
Systematic Name	Ydr226wp
Alias	Aky1p , Aky2p 2, 3
ORF Classification	Verified
Description	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress (1, 4, 5, 6)
Name Description	ADenylate Kinase 1

Experimental Data
Molecules/cell	123000 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	222
Molecular Weight (Da)	24,255
Isoelectric Point (pI)	6.37

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Adk1p (InterPro)
Physical Interactions	There are 36 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012DB8F \| P07170 MIPS: YDR226W NCBI: 125153 \| 1421658 \| 1421659 \| 157829936 \| 157834546 \| 157836762 \| 171032 \| 3341 \| 3357 \| 45271046 \| 532750 \| 6320432 \| 728682 \| NP_010512.1 GenBank/EMBL/DDBJ: DAA12068.1 \| AY558578 \| M18455 \| U13239 \| X06304 \| Y00413 \| Z48612
External Classifications	EC: 2.7.4.3 [Adenylate kinase]

Amino Acid Sequence (or in FASTA format)
1 MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ 51 LGLEAKKIMD QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA 101 EKLDQMLKEQ GTPLEKAIEL KVDDELLVAR ITGRLIHPAS GRSYHKIFNP 151 PKEDMKDDVT GEALVQRSDD NADALKKRLA AYHAQTEPIV DFYKKTGIWA 201 GVDASQPPAT VWADILNKLG KD*

Amino Acid Sequence (or in FASTA format)

       1  MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ
      51  LGLEAKKIMD QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA
     101  EKLDQMLKEQ GTPLEKAIEL KVDDELLVAR ITGRLIHPAS GRSYHKIFNP
     151  PKEDMKDDVT GEALVQRSDD NADALKKRLA AYHAQTEPIV DFYKKTGIWA
     201  GVDASQPPAT VWADILNKLG KD*

external links for Adk1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Adk1p

1)	Konrad M (1988) Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. J Biol Chem 263(36):19468-74
2)	Oechsner U, et al. (1988) Yeast adenylate kinase is transcribed constitutively from a promoter in the short intergenic region to the histone H2A-1 gene. FEBS Lett 242(1):187-93
3)	Schricker R, et al. (2002) Redundant mitochondrial targeting signals in yeast adenylate kinase. J Biol Chem 277(32):28757-64
4)	Klier H, et al. (1996) Cytoplasmic and mitochondrial forms of yeast adenylate kinase 2 are N-acetylated. Biochim Biophys Acta 1280(2):251-6
5)	Rebora K, et al. (2001) Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Mol Cell Biol 21(23):7901-12
6)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41