HTB1/YDR224C Protein Information Help

Standard Name Htb1p
Systematic Name Ydr224cp
Alias Spt12p 1
ORF Classification Verified
Description Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation (2, 3, 4, 5, 6, 7, 8)
Name Description Histone h Two B 9
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 131
Molecular Weight (Da) 14,252
Isoelectric Point (pI) 10.92

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Htb1p (InterPro)
Physical Interactions There are 267 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F8F7 | P02293
MIPS: YDR224C
NCBI: 122024 | 171633 | 188595808 | 398366183 | 45269339 | 532748 | 728680 | 7544605 | NP_010510.3
GenBank/EMBL/DDBJ: DAA12066.1 | AY557724 | J01327 | M37743 | U13239 | Z48612
Amino Acid Sequence (or in FASTA format)
 
       1  MSAKAEKKPA SKAPAEKKPA AKKTSTSTDG KKRSKARKET YSSYIYKVLK
      51  QTHPDTGISQ KSMSILNSFV NDIFERIATE ASKLAAYNKK STISAREIQT
     101  AVRLILPGEL AKHAVSEGTR AVTKYSSSTQ A*

external links for Htb1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Htb1p
1) Sherwood PW and Osley MA  (1991) Histone regulatory (hir) mutations suppress delta insertion alleles in Saccharomyces cerevisiae. Genetics 128(4):729-38
2) Robzyk K, et al.  (2000) Rad6-dependent ubiquitination of histone H2B in yeast. Science 287(5452):501-4
3) Martini EM, et al.  (2002) A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. Genetics 160(4):1375-87
4) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
5) Briggs SD, et al.  (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418(6897):498
6) Hwang WW, et al.  (2003) A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell 11(1):261-6
7) Kao CF, et al.  (2004) Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev 18(2):184-95
8) Yamashita K, et al.  (2004) Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis. Proc Natl Acad Sci U S A 101(31):11380-5
9) Wallis JW, et al.  (1980) Histone H2B genes of yeast encode two different proteins. Cell 22(3):799-805