MSC2/YDR205W Protein Information Help

Standard Name Msc2p 1
Systematic Name Ydr205wp
ORF Classification Verified
Description Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids (1, 2, 3)
Name Description Meiotic Sister-Chromatid recombination 1
Experimental Data
Molecules/cell 1070 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 724
Molecular Weight (Da) 80,577
Isoelectric Point (pI) 7.76

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Msc2p (InterPro)
Transmembrane Domains There are 13 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001D4771 | Q03455
MIPS: YDR205W
NCBI: 1122333 | 398366087 | 41017298 | NP_010491.4 | NM_001180513.3
GenBank/EMBL/DDBJ: DAA12046.1 | Z68194
External Classifications TC: 2.A.4.4
Amino Acid Sequence (or in FASTA format)
 
       1  MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL
      51  IFFSTDHAIR LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL
     101  SILTAIFHPI QSTCITLLII KLLTTADESS PKIALNFKTI LKTFVPFITL
     151  TLVILRWDPS FDASSGDVNK ISTSLAAYAL LILTLRYASP LILSTLSSSI
     201  GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV NKTYNIQLLM
     251  VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ EDEYCRMFDI KYMISYLWLT
     301  RFTILLTGIM AIVVHFLSFN EITSSIKTDL LSLLFVVVAE YVSSFSNKQP
     351  DSHSHNHAHH HSHLTDSLPL ENESMFKQMA LNKDTRSIFS FLLLNTAFMF
     401  VQLLYSFRSK SLGLLSDSLH MALDCTSLLL GLIAGVLTKK PASDKFPFGL
     451  NYLGTLAGFT NGVLLLGIVC GIFVEAIERI FNPIHLHATN ELLVVATLGL
     501  LVNLVGLFAF DHGAHDHGGT DNENMKGIFL HILADTLGSV GVVISTLLIK
     551  LTHWPIFDPI ASLLIGSLIL LSALPLLKST SANILLRLDD KKHNLVKSAL
     601  NQISTTPGIT GYTTPRFWPT ESGSSGHSHA HTHSHAENHS HEHHHDQKNG
     651  SQEHPSLVGY IHVQYVDGEN STIIKKRVEK IFENVSIKAW VQVEPQNSTC
     701  WCRATSMNTI SANPNSLPLQ PIAN*

external links for Msc2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Msc2p
1) Thompson DA and Stahl FW  (1999) Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics 153(2):621-41
2) Li L and Kaplan J  (2001) The yeast gene MSC2, a member of the cation diffusion facilitator family, affects the cellular distribution of zinc. J Biol Chem 276(7):5036-43
3) Cyert MS and Philpott CC  (2013) Regulation of cation balance in Saccharomyces cerevisiae. Genetics 193(3):677-713
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41