CAB5/YDR196C Protein Information

Standard Name	Cab5p 1
Systematic Name	Ydr196cp
ORF Classification	Verified
Description	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies (1, 2, 3, 4, 5)

Experimental Data
Molecules/cell	1660 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	241
Molecular Weight (Da)	27,340
Isoelectric Point (pI)	8.83

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cab5p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052ECC \| Q03941 MIPS: YDR196C NCBI: 2833198 \| 398366057 \| 45269251 \| 755789 \| NP_010482.3 GenBank/EMBL/DDBJ: DAA12039.1 \| AY557679 \| Z48784

Amino Acid Sequence (or in FASTA format)
1 MLVVGLTGGI ACGKSTVSRR LRDKYKLPIV DADKIARQVV EPGQNAYDQI 51 VLYFKDKIPN LLLEDGHLNR EALGKWVFSH KEDLQALNGI THPAIRYAMF 101 KEIGYYYLKG YRMCVLDVPL LFEGNLDSIC GVTVSVICTQ ELQLERLMTR 151 NPELSEEDAK NRLNSQMSTE ERMARSDYIL QNNSTLVDLY EQIESVVKKI 201 QPSKLRTVLE YFPPFGAVSA SSIVMSRLLM KKLQNKKSSA V*

Amino Acid Sequence (or in FASTA format)

       1  MLVVGLTGGI ACGKSTVSRR LRDKYKLPIV DADKIARQVV EPGQNAYDQI
      51  VLYFKDKIPN LLLEDGHLNR EALGKWVFSH KEDLQALNGI THPAIRYAMF
     101  KEIGYYYLKG YRMCVLDVPL LFEGNLDSIC GVTVSVICTQ ELQLERLMTR
     151  NPELSEEDAK NRLNSQMSTE ERMARSDYIL QNNSTLVDLY EQIESVVKKI
     201  QPSKLRTVLE YFPPFGAVSA SSIVMSRLLM KKLQNKKSSA V*

external links for Cab5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cab5p

1)	Olzhausen J, et al. (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55(2):163-73
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Tatusov RL, et al. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28(1):33-6
4)	Daugherty M, et al. (2002) Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem 277(24):21431-9
5)	Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41