MSS116/YDR194C Protein Information Help

Standard Name Mss116p
Systematic Name Ydr194cp
ORF Classification Verified
Description DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing (1, 2)
Name Description Mitochondrial Splicing System 3
Experimental Data
Molecules/cell 10300 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 664
Molecular Weight (Da) 76,268
Isoelectric Point (pI) 9.69

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mss116p (InterPro)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 23 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F596 | P15424
MIPS: YDR194C
NCBI: 127324 | 257471982 | 257471984 | 257471986 | 257471988 | 350610602 | 350610604 | 402550313 | 402550314 | 402550315 | 402550316 | 402550323 | 402550324 | 6320400 | 755787 | NP_010480.1 | NM_001180502.1
GenBank/EMBL/DDBJ: DAA12036.1 | Z48784
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MLTSILIKGR TPVLASRNLL AALSNCNHIT WAVSRRLYND GNRDQRNFGR
      51  NQRNNNSNRY RNSRFNSRPR TRSREDDDEV HFDKTTFSKL IHVPKEDNSK
     101  EVTLDSLLEE GVLDKEIHKA ITRMEFPGLT PVQQKTIKPI LSSEDHDVIA
     151  RAKTGTGKTF AFLIPIFQHL INTKFDSQYM VKAVIVAPTR DLALQIEAEV
     201  KKIHDMNYGL KKYACVSLVG GTDFRAAMNK MNKLRPNIVI ATPGRLIDVL
     251  EKYSNKFFRF VDYKVLDEAD RLLEIGFRDD LETISGILNE KNSKSADNIK
     301  TLLFSATLDD KVQKLANNIM NKKECLFLDT VDKNEPEAHE RIDQSVVISE
     351  KFANSIFAAV EHIKKQIKER DSNYKAIIFA PTVKFTSFLC SILKNEFKKD
     401  LPILEFHGKI TQNKRTSLVK RFKKDESGIL VCTDVGARGM DFPNVHEVLQ
     451  IGVPSELANY IHRIGRTARS GKEGSSVLFI CKDELPFVRE LEDAKNIVIA
     501  KQEKYEPSEE IKSEVLEAVT EEPEDISDIV ISLISSYRSC IKEYRFSERR
     551  ILPEIASTYG VLLNDPQLKI PVSRRFLDKL GLSRSPIGKA MFEIRDYSSR
     601  DGNNKSYDYD DDSEISFRGN KNYNNRSQNR DYDDEPFRRS NNNRRSFSRS
     651  NDKNNYSSRN SNIY*

external links for Mss116p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Mss116p
1) Huang HR, et al.  (2005) The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function. Proc Natl Acad Sci U S A 102(1):163-8
2) Halls C, et al.  (2007) Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity. J Mol Biol 365(3):835-55
3) Faye G and Simon M  (1983) "Processing of the oxi-3 pre-messenger RNA in yeast." Pp. 433-439 in Mitochondria 1983: Nucleo-Mitochondrial Interactions, edited by Schweyen RJ, Wolf K, Kaudewitz F
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41