NUP42/YDR192C Protein Information

Standard Name	Nup42p 1
Systematic Name	Ydr192cp
Alias	Rip1p 1 , Uip1p 2
ORF Classification	Verified
Description	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p (3, 4, 5, 6, 7, 8)
Name Description	NUclear Pore 9

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	430
Molecular Weight (Da)	42,778
Isoelectric Point (pI)	10.73

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nup42p (InterPro)
Physical Interactions	There are 82 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013071C \| P49686 MIPS: YDR192C NCBI: 1352564 \| 398366037 \| 51830245 \| 755786 \| 950163 \| NP_010478.3 GenBank/EMBL/DDBJ: DAA12035.1 \| AY723779 \| U30614 \| Z48784

Amino Acid Sequence (or in FASTA format)
1 MSAFGNPFTS GAKPNLSNTS GINPFTNNAA STNNMGGSAF GRPSFGTANT 51 MTGGTTTSAF GMPQFGTNTG NTGNTSISAF GNTSNAAKPS AFGAPAFGSS 101 APINVNPPST TSAFGAPSFG STGFGAMAAT SNPFGKSPGS MGSAFGQPAF 151 GANKTAIPSS SVSNSNNSAF GAASNTPLTT TSPFGSLQQN ASQNASSTSS 201 AFGKPTFGAA TNTQSPFGTI QNTSTSSGTG VSPFGTFGTN SNNKSPFSNL 251 QSGAGAGSSP FGTTTSKANN NNNVGSSAFG TTNNQSPFSG GSGGTFGSAS 301 NLNKNTNGNF QSSFGNKGFS FGITPQNDAN KVSQSNPSFG QTMPNTDPNI 351 SLKSNGNATS FGFGQQQMNA TNVNANTATG KIRFVQGLSS EKDGILELAD 401 LAEETLKIFR ANKFELGLVP DIPPPPALVA *

Amino Acid Sequence (or in FASTA format)

       1  MSAFGNPFTS GAKPNLSNTS GINPFTNNAA STNNMGGSAF GRPSFGTANT
      51  MTGGTTTSAF GMPQFGTNTG NTGNTSISAF GNTSNAAKPS AFGAPAFGSS
     101  APINVNPPST TSAFGAPSFG STGFGAMAAT SNPFGKSPGS MGSAFGQPAF
     151  GANKTAIPSS SVSNSNNSAF GAASNTPLTT TSPFGSLQQN ASQNASSTSS
     201  AFGKPTFGAA TNTQSPFGTI QNTSTSSGTG VSPFGTFGTN SNNKSPFSNL
     251  QSGAGAGSSP FGTTTSKANN NNNVGSSAFG TTNNQSPFSG GSGGTFGSAS
     301  NLNKNTNGNF QSSFGNKGFS FGITPQNDAN KVSQSNPSFG QTMPNTDPNI
     351  SLKSNGNATS FGFGQQQMNA TNVNANTATG KIRFVQGLSS EKDGILELAD
     401  LAEETLKIFR ANKFELGLVP DIPPPPALVA *

external links for Nup42p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Nup42p

1)	SGD (2009) Gene name standardized from a GenBank/EMBL/DDBJ record
2)	Takahashi Y, et al. (2000) Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. J Biochem 128(5):723-5
3)	Strahm Y, et al. (1999) The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p. EMBO J 18(20):5761-77
4)	Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
5)	Allen NP, et al. (2001) Proteomic analysis of nucleoporin interacting proteins. J Biol Chem 276(31):29268-74
6)	Patel SS, et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129(1):83-96
7)	Light WH, et al. (2010) Interaction of a DNA Zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol Cell 40(1):112-25
8)	Bradatsch B, et al. (2007) Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit. Mol Cell 27(5):767-79
9)	Davis LI and Fink GR (1990) The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Cell 61(6):965-78