PLP1/YDR183W Protein Information

Standard Name	Plp1p 1
Systematic Name	Ydr183wp
ORF Classification	Verified
Description	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators (1, 2, 3, 4)
Name Description	Phosducin-Like Protein 1

Experimental Data
Molecules/cell	2250 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	230
Molecular Weight (Da)	26,622
Isoelectric Point (pI)	4.89

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Plp1p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A8BF \| Q04004 MIPS: YDR183W NCBI: 1289300 \| 398366005 \| 45271040 \| 6136668 \| NP_010469.3 GenBank/EMBL/DDBJ: DAA12027.1 \| AY558575 \| Z46727

Amino Acid Sequence (or in FASTA format)
1 MEDKLDRYYT NVLSNAEKDK HTTVDSDDKS SGEENLDELL NELDRELDED 51 HEFLSAYRSE RLQQISDHLK QVKKNVEDDG YGRLQCIDNE ADAIQICTKT 101 TMVVIHFELE TFGKCQYMNE KLENLAKRYL TTRFIKVNVQ TCPFLVNKLN 151 IKVLPFVVGY KNGLEKVRYV GFSKLGNDPN GFDIRRLEQS LAHSGVIEDT 201 FEIRKHSSVN TERFASTNHD RSESDSDLDI *

Amino Acid Sequence (or in FASTA format)

       1  MEDKLDRYYT NVLSNAEKDK HTTVDSDDKS SGEENLDELL NELDRELDED
      51  HEFLSAYRSE RLQQISDHLK QVKKNVEDDG YGRLQCIDNE ADAIQICTKT
     101  TMVVIHFELE TFGKCQYMNE KLENLAKRYL TTRFIKVNVQ TCPFLVNKLN
     151  IKVLPFVVGY KNGLEKVRYV GFSKLGNDPN GFDIRRLEQS LAHSGVIEDT
     201  FEIRKHSSVN TERFASTNHD RSESDSDLDI *

external links for Plp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
YGOB	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Plp1p

1)	Flanary PL, et al. (2000) Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast. J Biol Chem 275(24):18462-9
2)	Lacefield S and Solomon F (2003) A novel step in beta-tubulin folding is important for heterodimer formation in Saccharomyces cerevisiae. Genetics 165(2):531-41
3)	Stirling PC, et al. (2006) PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. J Biol Chem 281(11):7012-21
4)	Dekker C, et al. (2008) The interaction network of the chaperonin CCT. EMBO J 27(13):1827-39
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41