SCC2/YDR180W Protein Information Help

Standard Name Scc2p 1
Systematic Name Ydr180wp
ORF Classification Verified
Description Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4, 5, 6)
Name Description Sister Chromatid Cohesion 1
Experimental Data
Molecules/cell 3310 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,493
Molecular Weight (Da) 171,100
Isoelectric Point (pI) 6.82

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Scc2p (InterPro)
Physical Interactions There are 33 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013562D | Q04002
MIPS: YDR180W
NCBI: 1289297 | 23822152 | 2570098 | 398365987 | NP_010466.3 | NM_001180488.3
GenBank/EMBL/DDBJ: DAA12023.1 | Y14279 | Z46727
Amino Acid Sequence (or in FASTA format)
 
       1  MSYPGKDKNI PGRIIEALED LPLSYLVPKD GLAALVNAPM RVSLPFDKTI
      51  FTSADDGRDV NINVLGTANS TTSSIKNEAE KERLVFKRPS NFTSSANSVD
     101  YVPTNFLEGL SPLAQSVLST HKGLNDSINI EKKSEIVSRP EAKHKLESVT
     151  SNAGNLSFND NSSNKKTKTS TGVTMTQANL AEQYLNDLKN ILDIVGFDQN
     201  SAEIGNIEYW LQLPNKKFVL TTNCLTKLQM TIKNITDNPQ LSNSIEITWL
     251  LRLLDVMVCN IKFSKSSLKM GLDDSMLRYI ALLSTIVLFN IFLLGKNDSN
     301  LHRESYIMEP VNFLSDLIES LKILTIEYGS LKIEFDTFQE ALELLPKYIR
     351  NGPFLDDNVT AKLVYIFSDL LMNNDIEATT NIQFQSFWDN VKRISSDILV
     401  SLFGSFDQQR GFIIEELLSH IEKLPTKRIQ KKLRKVGNQN IYITDFTFTL
     451  MSMLENINCY SFCNQMKDIA PENIDLLKNE YKKQEEFLFN IVEHINDTIL
     501  ERFFKNPSAL RYVIDNFVQD LLLLISSPQW PVTEKILSSL LKRLLSVYSP
     551  SMQVSANIET ICLQLIGNIG STIFDIKCST RDHEDNNLIK MINYPETLPH
     601  FFKSFEECIA YNETIKCRRS ATRFLWNLRL GTILILEEYT KDAKEQIITV
     651  DNELKKILEQ IKDGGLGPEL ENREADFSTI KLDYFSILHA FELLNLYDPY
     701  LKLILSLLAK DKIKLRSTAI KCLSMLASKD KVILSNPMVK ETIHRRLNDS
     751  SASVKDAILD LVSINSSYFE FYQQINNNYN DDSIMVRKHV LRINEKMYDE
     801  TNDIVTKVYV IARILMKIED EEDNIIDMAR LILLNRWILK VHEVLDQPEK
     851  LKEISSSVLL VMSRVAIMNE KCSQLFDLFL NFYLLNKEAH SKEAYDKITH
     901  VLTILTDFLV QKIVELNSDD TNEKNSIVDK QNFLNLLAKF ADSTVSFLTK
     951  DHITALYPYM VSDEKSDFHY YILQVFRCTF EKLANFKQKF LYDLETTLLS
    1001  RLPKMNVREI DEAMPLIWSV ATHRHDTARV AKACSSCLSH LHPYINKANN
    1051  EEAAIVVDGK LQRLIYLSTG FARFCFPKPS NDKIAFLQEG ETLYEHITKC
    1101  LLVLSKDKIT HVIRRVAVKN LTKLCGNHPK LFNSRHVLHL LDKEFQSDQL
    1151  DIKLVILESL YDLFLLEERK SVRNTGVNST LSSNSILKKK LLKTNRVEFA
    1201  NDGVCSALAT RFLDNILQLC LLRDLKNSLV AIRLLKLILK FGYTNPSHSI
    1251  PTVIALFAST SQYIRHVAYE LLEDLFEKYE TLVFSSLSRG VTKAIHYSIH
    1301  TDEKYYYKHD HFLSLLEKLC GTGKKNGPKF FKVLKRIMQS YLDDITDLTS
    1351  TNSSVQKSIF VLCTNISNIT FVSQYDLVSL LKTIDLTTDR LKEVIMDEIG
    1401  DNVSSLSVSE EKLSGIILIQ LSLQDLGTYL LHLYGLRDDV LLLDIVEESE
    1451  LKNKQLPAKK PDISKFSAQL ENIEQYSSNG KLLTYFRKHV KDT*

external links for Scc2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Scc2p
1) Michaelis C, et al.  (1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91(1):35-45
2) Ciosk R, et al.  (2000) Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell 5(2):243-54
3) Unal E, et al.  (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16(6):991-1002
4) Strom L, et al.  (2004) Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol Cell 16(6):1003-15
5) Furuya K, et al.  (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev 12(21):3408-18
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41