SDH4/YDR178W Protein Information

Standard Name	Sdh4p 1
Systematic Name	Ydr178wp
Alias	Acn18p
ORF Classification	Verified
Description	Membrane anchor subunit of succinate dehydrogenase; involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; SDH4 has a paralog, SHH4, that arose from the whole genome duplication (2, 3)
Name Description	Succinate DeHydrogenase 1

Experimental Data
Molecules/cell	7920 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	181
Molecular Weight (Da)	20,248
Isoelectric Point (pI)	9.59

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sdh4p (InterPro)
Transmembrane Domains	There are 2 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F8F4 \| P37298 MIPS: YDR178W NCBI: 1289293 \| 430739 \| 45269235 \| 585976 \| 6320383 \| NP_010463.1 GenBank/EMBL/DDBJ: DAA12020.1 \| AY557671 \| L26333 \| Z46727
External Classifications	EC: 1.3.5.1 [Succinate dehydrogenase (ubiquinone)]

Amino Acid Sequence (or in FASTA format)
1 MMLPRSMKFM TGRRIFHTAT VRAFQSTAKK SLTIPFLPVL PQKPGGVRGT 51 PNDAYVPPPE NKLEGSYHWY MEKIFALSVV PLATTAMLTT GPLSTAADSF 101 FSVMLLGYCY MEFNSCITDY ISERVYGVWH KYAMYMLGLG SAVSLFGIYK 151 LETENDGVVG LVKSLWDSSE KDNSQKIEAK K*

Amino Acid Sequence (or in FASTA format)

       1  MMLPRSMKFM TGRRIFHTAT VRAFQSTAKK SLTIPFLPVL PQKPGGVRGT
      51  PNDAYVPPPE NKLEGSYHWY MEKIFALSVV PLATTAMLTT GPLSTAADSF
     101  FSVMLLGYCY MEFNSCITDY ISERVYGVWH KYAMYMLGLG SAVSLFGIYK
     151  LETENDGVVG LVKSLWDSSE KDNSQKIEAK K*

external links for Sdh4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sdh4p

1)	Chapman KB, et al. (1992) SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Gene 118(1):131-6
2)	Oyedotun KS and Lemire BD (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279(10):9424-31
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41