NGG1/YDR176W Protein Information Help

Standard Name Ngg1p
Systematic Name Ydr176wp
Alias Ada3p , Swi7p 1
ORF Classification Verified
Description Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex (2, 3, 4, 5)
Experimental Data
Molecules/cell 2470 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 702
Molecular Weight (Da) 79,281
Isoelectric Point (pI) 4.84

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ngg1p (InterPro)
Physical Interactions There are 194 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053128 | P32494
MIPS: YDR176W
NCBI: 1289291 | 172040 | 398365963 | 405594 | 417358 | NP_010461.3
GenBank/EMBL/DDBJ: DAA12018.1 | L12137 | L21189 | Z46727
Amino Acid Sequence (or in FASTA format)
 
       1  MPRHGRRGKL PKGEKLPKKE GGDNTPSKLL SSMLKTLDLT FERDIGMLNG
      51  KSVRSIPNKK TLLELQSQLD SLNEILGTIA RGDQETIEAL RKIRDSKNEK
     101  QANDEKQETS NADGQHESST ATEETNIIDK GVQSPPKPPP SNEISGTIEN
     151  DVESIKQAAD NMAKEEINED KDLQVHRDQP REKRPFDSET ENRATENENT
     201  QRPDNKKQKI DVDKMENDPT VKNPKSEFVV SQTLPRAAAA LGLFNEEGLE
     251  STGEDFLKKK YNVASYPTND LKDLLPGELP DMDFSHPKPT NQIQFNTFLA
     301  FVENFFKDLS DDNLKFLKMK YIIPDSLQFD KTYDPEVNPF IIPKLGPLYT
     351  DVWFKDENDK NSAYKKPSPY SNDASTILPK KSANELDDNA LESGSISCGP
     401  LLSRLLSAVL KDDNDKSELQ SSKIIRDGGL PRTGGEDDIQ SFRNNNNDTV
     451  DMTLSQENGP SVQTPDNDID EEASFQAKLA ENKGSNGGTT STLPQQIGWI
     501  TNGINLDYPT FEERLKRELK YVGIYMNLPK DENNPNSDDP DWVTGREDDE
     551  ISAELRELQG TLKQVTKKNQ KRKAQLIPLV ERQLAWQEYS SILEDLDKQI
     601  DQAYVKRIRV PKKRKKHHTA ASNNVNTGTT SQIAQQKAAN SSLKSLLDKR
     651  QRWINKIGPL FDKPEIMKRI PNESVFKDMD QEEDEDEADV FAQNTNKDVE
     701  LN*

external links for Ngg1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome

YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ngg1p
1) Breeden L and Nasmyth K  (1987) Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell 48(3):389-97
2) Saleh A, et al.  (1997) Identification of native complexes containing the yeast coactivator/repressor proteins NGG1/ADA3 and ADA2. J Biol Chem 272(9):5571-8
3) Brandl CJ, et al.  (1993) Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p-regulated transcription. EMBO J 12(13):5255-65
4) Grant PA, et al.  (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53
5) Pray-Grant MG, et al.  (2002) The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway. Mol Cell Biol 22(24):8774-86
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41