PEX7/YDR142C Protein Information

Standard Name	Pex7p 1
Systematic Name	Ydr142cp
Alias	Pas7p 2 , Peb1p 3
ORF Classification	Verified
Description	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) (3, 4, 5)
Name Description	PEroXin 1

Experimental Data
Molecules/cell	589 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	375
Molecular Weight (Da)	42,323
Isoelectric Point (pI)	8.34

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pex7p (InterPro)
Physical Interactions	There are 60 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001316F6 \| P39108 MIPS: YDR142C NCBI: 45269293 \| 558715 \| 6320346 \| 730272 \| 791125 \| 836649 \| 984174 \| NP_010426.1 \| NM_001180449.1 GenBank/EMBL/DDBJ: DAA11985.1 \| AY557700 \| X81424 \| X83704 \| Z48179 \| Z54139

Amino Acid Sequence (or in FASTA format)
1 MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR 51 IVEVNSFLTQ DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF 101 KEHEREVFSC NWNLVNRQNF LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI 151 TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA QFSPHDQNLV LSCSGNSYAS 201 LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG VDNAIRIWDI 251 RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM 301 SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW 351 SLWGKPGYVA STAWDGNLFV WNGLG*

Amino Acid Sequence (or in FASTA format)

       1  MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR
      51  IVEVNSFLTQ DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF
     101  KEHEREVFSC NWNLVNRQNF LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI
     151  TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA QFSPHDQNLV LSCSGNSYAS
     201  LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG VDNAIRIWDI
     251  RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM
     301  SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW
     351  SLWGKPGYVA STAWDGNLFV WNGLG*

external links for Pex7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Pex7p

1)	Distel B, et al. (1996) A unified nomenclature for peroxisome biogenesis factors. J Cell Biol 135(1):1-3
2)	Marzioch M, et al. (1994) PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. EMBO J 13(20):4908-18
3)	Zhang JW and Lazarow PB (1995) PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes. J Cell Biol 129(1):65-80
4)	Erdmann R and Blobel G (1996) Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor. J Cell Biol 135(1):111-21
5)	Purdue PE, et al. (1998) Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J Cell Biol 143(7):1859-69
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41