DOP1/YDR141C Protein Information Help

Standard Name Dop1p 1
Systematic Name Ydr141cp
ORF Classification Verified
Description Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies (1, 2, 3, 4, 5)
Name Description homolog of A. nidulans DOPey 1
Experimental Data
Molecules/cell 2700 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,698
Molecular Weight (Da) 194,685
Isoelectric Point (pI) 5.49

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Dop1p (InterPro)
Physical Interactions There are 30 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006AE4F | Q03921
MIPS: YDR141C
NCBI: 6320345 | 665674 | 74583435 | NP_010425.1 | NM_001180448.1
GenBank/EMBL/DDBJ: DAA11984.1 | Z48179
Amino Acid Sequence (or in FASTA format)
 
       1  MSLPLKPLTI DSNNKQLDSK QKKFRANVER ALERFDSVTE WADYIASLGT
      51  LLKALQSWSP KFQNVRYYVP SPYQVSRRLT SSLSPALPAG VHQKTLEVYT
     101  YIFEHIGLET LATECNIWIP GILPLMTYAS MSVRSHLIEL YDNYILLLPQ
     151  TTLRLLIRPL ISSLLPGIDD ESNDFLPLTL KLIETLQENL DDDSLFWQTL
     201  FLVMTANKGR RLGGLTWLTR KFPSLNAVPH LVNKIKMEAE ENPSETETND
     251  SHLDRKKRKE EAFKVLLPAA KDLVTPEPGL LIRCLVGCLE DENDILIKRS
     301  VLDLLLQRLR LDSPVLNVLI TSEDKKLLIM SCCRTTLSKD MSLNRRIWNW
     351  LLGPTAGGML NNNGGNSMEY TTSVKSANEE SNVYFTKYGL SALLEGLSDL
     401  LSEEESVLTA FRISMAVMDR WEIGSLVIPE LFIPLLYSSE KFKQNEQIMK
     451  TARTFFDNTE TNIIWGKLFQ ELEDIKNLKI LDFVLTNFNI GNDEEIIVRH
     501  LPLILLTLLA LPSNDKDFDN IYKLQKFSLY NKLLNYIPER ALLPLSHSKL
     551  KHDDEVSCEE LLAKIRGFYT NVSNPSSILE KENIAERLPP FTTEDLTFLI
     601  ADLIQKKLLS SLWDLENINE SSKLFIAIFE KIPESEELKG RSHISWSDKK
     651  ITQSIFEAIP RLCESNNDAK SEEIVGIVEI FGNYLYSRME FIESMKLLKV
     701  VMMAVWKSLK DPRHQILGVK NLKTLNRFIP SKFIESALVY TFVEEEDISE
     751  RLSVLDLLWT QLDSDSNLIR RPLELILGEL FDDQNPFYLT VSKWILSILN
     801  SGSASRLFYI LTDNILKVNR LEKERLDERD DLDMLTYEFQ MLAYVLKTNN
     851  GRTRKVFSTE LTSIKSSTIW KNEDVSTYKS LLLVTLMRFL NIKSNTHAKS
     901  IRSALILLDI LLDGTEQNFK DIVIFLLQMS SKYIAEEGIE PELIAVSLLD
     951  IVSKVLRLSH DNGIKLDIFD DNAAHLKYID FLVTSVSNMK SPLIVTAYVK
    1001  LLSESIVYFE NSIFRMILPL SASLVQCVQR LFLLEKREGG YYQPIALLLG
    1051  GLEELLEISH GYLVTEEREG YFSGSNLKGD FIQSVVSNVF SSDSSNEESK
    1101  IQGERDVILQ SFRQVISCCL DIWYWAHNIS CKSNDDSSLD ATNHNSYKFK
    1151  FRSKKLLETL FLLEPLELLE NLISIRSDNT TVTLVHVLDG NKPAITIPHL
    1201  LYGVIIRYNR TASVKFSNRD GSRSSTTKLT KGEPSMLKRL SGESIIAFLF
    1251  NYVDSVENSA MEEFYGDFLL FFREVATNYN LYSDVSLSIL KLVALISGKV
    1301  SKTQFGEQKR VRREISDVFF KYLPNAFINF TNLYRGHPDS FKDLEFVVWR
    1351  VQYIVNDQIG GDKFNTTLAT IVNQCLTPYI KPKSEKTIPG YVLELAAVVS
    1401  HLGSKVKSWR LLIAELFQND KKLSVIGSDQ TWEKIIYEWS IYPENKSKIL
    1451  NDLLLEIGSK RSSVTPTLIT FNLGSDSEVE YKCQNLLKIS YLLMVSPNDA
    1501  YLLHFSSLIS CIFHYLVSKD IKLKGSCWIL LRVLLLRFSE SHFNDYWSMI
    1551  SYCLQTNLQE FYESLQIQSE VDPQTILQVC KTLDLLLLLN MEGFTSTNEW
    1601  IFVIDTINCV YKTNSFVALV DEIAEFKDYE ITKTDDLELP TTLKDGLPLL
    1651  RGIHKIERHT QLRSFFQNLS YLHYEKVYGL GSVDLYGCGE DLKKDILS*

external links for Dop1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Dop1p
1) Pascon RC and Miller BL  (2000) Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Mol Microbiol 36(6):1250-64
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Gillingham AK, et al.  (2006) Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. J Biol Chem 281(4):2273-80
5) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41