MTQ2/YDR140W Protein Information

Standard Name	Mtq2p 1
Systematic Name	Ydr140wp
ORF Classification	Verified
Description	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC (1, 2, 3, 4)
Name Description	Methyltransferase 1

Experimental Data
Molecules/cell	3390 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	221
Molecular Weight (Da)	24,973
Isoelectric Point (pI)	4.81

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mtq2p (InterPro)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EE9 \| Q03920 MIPS: YDR140W NCBI: 398365791 \| 45269245 \| 665673 \| 74676352 \| NP_010424.3 \| NM_001180447.3 GenBank/EMBL/DDBJ: DAA11983.1 \| AY557676 \| Z48179
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases]

Amino Acid Sequence (or in FASTA format)
1 MLPTPYVKCD YDKVYEPAED SFLILDCLEK EHDFLKQKFG NRLAIVCEIG 51 SGSGIVTTFL MQNKIIPQEN SIHLAVDINP WALEATLDTA KLNSCKSSFL 101 EVIQADLNSS IRNNQVDVLI FNPPYVPAEC VPDVPGSREE ADQWLDLALL 151 GGKDGMAITD KLLRQLEQIL SPDGVAYILF CARNKPKEVI KRFVDTYKWN 201 VKLIETRKAG WEVLSVYSFT R*

Amino Acid Sequence (or in FASTA format)

       1  MLPTPYVKCD YDKVYEPAED SFLILDCLEK EHDFLKQKFG NRLAIVCEIG
      51  SGSGIVTTFL MQNKIIPQEN SIHLAVDINP WALEATLDTA KLNSCKSSFL
     101  EVIQADLNSS IRNNQVDVLI FNPPYVPAEC VPDVPGSREE ADQWLDLALL
     151  GGKDGMAITD KLLRQLEQIL SPDGVAYILF CARNKPKEVI KRFVDTYKWN
     201  VKLIETRKAG WEVLSVYSFT R*

external links for Mtq2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mtq2p

1)	Polevoda B, et al. (2006) The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p. J Biol Chem 281(5):2562-71
2)	Heurgue-Hamard V, et al. (2005) The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene. J Biol Chem 280(4):2439-45
3)	Heurgue-Hamard V, et al. (2006) The Zinc Finger Protein Ynr046w Is Plurifunctional and a Component of the eRF1 Methyltransferase in Yeast. J Biol Chem 281(47):36140-8
4)	Studte P, et al. (2008) tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69(5):1266-77
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41