MTC5/YDR128W Protein Information Help

Standard Name Mtc5p 1
Systematic Name Ydr128wp
Alias Sea3p 2
ORF Classification Verified
Description Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress (1, 2, 3)
Name Description Maintenance of Telomere Capping 1
Experimental Data
Molecules/cell 556 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,148
Molecular Weight (Da) 130,945
Isoelectric Point (pI) 5.8

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mtc5p (InterPro)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006A370 | Q03897
MIPS: YDR128W
NCBI: 398365749 | 665660 | 74676351 | NP_010413.3
GenBank/EMBL/DDBJ: DAA11974.1 | Z48179
Amino Acid Sequence (or in FASTA format)
 
       1  MCSSINEGPY NSPTFGKSLS LKVDGGFNAV SINPSGRDIV LASRQGLYII
      51  DLDDPFTPPR WLHHITPWQV ADVQWSPHPA KPYWIVSTSN QKAIIWNLAK
     101  SSSNAIEFVL HGHSRAITDI NFNPQHPDVL ATCSVDTYVH AWDMRSPHRP
     151  FYSTSSWRSA ASQVKWNYKD PNVLASSHGN DIFVWDLRKG STPLCSLKGH
     201  VSSVNSIDFN RFKYSEIMSS SNDGTVKFWD YSKSTTESKR TVTTNFPIWR
     251  GRYLPFGEGY CIMPMVGGNN AVYLINLCDD DDSEQNKKTK LQPIYAFKGH
     301  SDRVIDFLWR SRHTCDGDYD DREFQLVTWS KDCDLKLWPI SDSIYGKVNF
     351  DRGKRLEEKL PDYDYCSYNK EPENRENVQK NEFRRLRENF VTTSGLKKNK
     401  TNHITWLSGI RMNSATSQED LFNETKIQNL GEEVSAIGHK FPKVVFEKIS
     451  VSTRELCLTL NGPWSEENPD DYIFLRISIN FPLNYPNKGD PPKFTIEENS
     501  NLTMSKRQEI LSNLATIGQK YTDSNLYCLE PCIRFVLGEK VSLEDIEEGQ
     551  EPLLNFDIAD HIDFEELSSL DSSYSDSQNP ENLSSQSDIE SYKEALVFPD
     601  TSNQGLDFGR NLALDTTPVP NGCGSCWTAT GELFCFFANE KKPEKKQNAI
     651  IKLSQKEAGV EKHPFKIEPQ VLYDKEVDSS VITAADELKA RPKRYVDTLG
     701  LGGGTNGDSR TYFDDETSSD DSFDSVADDW DDILRNDIIV RTKIPILRGN
     751  FKAFSSVHSE SGKTVESTKK NKNLVISKNF SSLLSDRKEL ALEYLFMDAT
     801  PEGFARNNAL VAEKFDLDEI SHCWQILSDM LIDQSDYDPY TTIWNNHPMG
     851  IKWFIKEAIV YFERQQNLQM LAMLCCVILS ARRKKIPARY YGQELENMEG
     901  TIVFNDNESQ NTSFWKGSDA FSTRSRSSTV TPNFYGNHLR GKNIHGGDNS
     951  SIRSDDHHAR LRTHNTLNGS SKFTEPAQKQ GSRAISSSPF HSRMPDIKVE
    1001  LLHDDIIEAY EQEDLLHLEV SDIPKFQTYI YQYSKLLFRW GLPLERVKIL
    1051  KVSTDFRSSY SSQGIPPNNN KKSPYNGVLT HWIENNEFGE EKFLARNCNY
    1101  CDLRVTRSSF ICGNCQHVLH SSCARIWWEI GDECPSGCGC NCPEMFDA*

external links for Mtc5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Mtc5p
1) Addinall SG, et al.  (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
2) Dokudovskaya S, et al.  (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics 10(6):M110.006478
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41