ARO1/YDR127W Protein Information

Standard Name	Aro1p
Systematic Name	Ydr127wp
ORF Classification	Verified
Description	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids (1, 2)
Name Description	AROmatic amino acid requiring

Experimental Data
Molecules/cell	6420 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,588
Molecular Weight (Da)	174,754
Isoelectric Point (pI)	6.23

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aro1p (InterPro)
Physical Interactions	There are 60 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F13 \| P08566 MIPS: YDR127W NCBI: 114166 \| 288353 \| 288355 \| 3381 \| 6320332 \| 665659 \| NP_010412.1 GenBank/EMBL/DDBJ: DAA11973.1 \| X06077 \| X13802 \| X13803 \| Z48179
External Classifications	EC: 1.1.1.25 [Shikimate dehydrogenase] EC: 2.5.1.19 [3-phosphoshikimate 1-carboxyvinyltransferase] EC: 2.7.1.71 [Shikimate kinase] EC: 4.2.1.10 [3-dehydroquinate dehydratase] EC: 4.2.3.4 [3-dehydroquinate synthase]

Amino Acid Sequence (or in FASTA format)
1 MVQLAKVPIL GNDIIHVGYN IHDHLVETII KHCPSSTYVI CNDTNLSKVP 51 YYQQLVLEFK ASLPEGSRLL TYVVKPGETS KSRETKAQLE DYLLVEGCTR 101 DTVMVAIGGG VIGDMIGFVA STFMRGVRVV QVPTSLLAMV DSSIGGKTAI 151 DTPLGKNFIG AFWQPKFVLV DIKWLETLAK REFINGMAEV IKTACIWNAD 201 EFTRLESNAS LFLNVVNGAK NVKVTNQLTN EIDEISNTDI EAMLDHTYKL 251 VLESIKVKAE VVSSDERESS LRNLLNFGHS IGHAYEAILT PQALHGECVS 301 IGMVKEAELS RYFGILSPTQ VARLSKILVA YGLPVSPDEK WFKELTLHKK 351 TPLDILLKKM SIDKKNEGSK KKVVILESIG KCYGDSAQFV SDEDLRFILT 401 DETLVYPFKD IPADQQKVVI PPGSKSISNR ALILAALGEG QCKIKNLLHS 451 DDTKHMLTAV HELKGATISW EDNGETVVVE GHGGSTLSAC ADPLYLGNAG 501 TASRFLTSLA ALVNSTSSQK YIVLTGNARM QQRPIAPLVD SLRANGTKIE 551 YLNNEGSLPI KVYTDSVFKG GRIELAATVS SQYVSSILMC APYAEEPVTL 601 ALVGGKPISK LYVDMTIKMM EKFGINVETS TTEPYTYYIP KGHYINPSEY 651 VIESDASSAT YPLAFAAMTG TTVTVPNIGF ESLQGDARFA RDVLKPMGCK 701 ITQTATSTTV SGPPVGTLKP LKHVDMEPMT DAFLTACVVA AISHDSDPNS 751 ANTTTIEGIA NQRVKECNRI LAMATELAKF GVKTTELPDG IQVHGLNSIK 801 DLKVPSDSSG PVGVCTYDDH RVAMSFSLLA GMVNSQNERD EVANPVRILE 851 RHCTGKTWPG WWDVLHSELG AKLDGAEPLE CTSKKNSKKS VVIIGMRAAG 901 KTTISKWCAS ALGYKLVDLD ELFEQQHNNQ SVKQFVVENG WEKFREEETR 951 IFKEVIQNYG DDGYVFSTGG GIVESAESRK ALKDFASSGG YVLHLHRDIE 1001 ETIVFLQSDP SRPAYVEEIR EVWNRREGWY KECSNFSFFA PHCSAEAEFQ 1051 ALRRSFSKYI ATITGVREIE IPSGRSAFVC LTFDDLTEQT ENLTPICYGC 1101 EAVEVRVDHL ANYSADFVSK QLSILRKATD SIPIIFTVRT MKQGGNFPDE 1151 EFKTLRELYD IALKNGVEFL DLELTLPTDI QYEVINKRGN TKIIGSHHDF 1201 QGLYSWDDAE WENRFNQALT LDVDVVKFVG TAVNFEDNLR LEHFRDTHKN 1251 KPLIAVNMTS KGSISRVLNN VLTPVTSDLL PNSAAPGQLT VAQINKMYTS 1301 MGGIEPKELF VVGKPIGHSR SPILHNTGYE ILGLPHKFDK FETESAQLVK 1351 EKLLDGNKNF GGAAVTIPLK LDIMQYMDEL TDAAKVIGAV NTVIPLGNKK 1401 FKGDNTDWLG IRNALINNGV PEYVGHTAGL VIGAGGTSRA ALYALHSLGC 1451 KKIFIINRTT SKLKPLIESL PSEFNIIGIE STKSIEEIKE HVGVAVSCVP 1501 ADKPLDDELL SKLERFLVKG AHAAFVPTLL EAAYKPSVTP VMTISQDKYQ 1551 WHVVPGSQML VHQGVAQFEK WTGFKGPFKA IFDAVTKE*

Amino Acid Sequence (or in FASTA format)

       1  MVQLAKVPIL GNDIIHVGYN IHDHLVETII KHCPSSTYVI CNDTNLSKVP
      51  YYQQLVLEFK ASLPEGSRLL TYVVKPGETS KSRETKAQLE DYLLVEGCTR
     101  DTVMVAIGGG VIGDMIGFVA STFMRGVRVV QVPTSLLAMV DSSIGGKTAI
     151  DTPLGKNFIG AFWQPKFVLV DIKWLETLAK REFINGMAEV IKTACIWNAD
     201  EFTRLESNAS LFLNVVNGAK NVKVTNQLTN EIDEISNTDI EAMLDHTYKL
     251  VLESIKVKAE VVSSDERESS LRNLLNFGHS IGHAYEAILT PQALHGECVS
     301  IGMVKEAELS RYFGILSPTQ VARLSKILVA YGLPVSPDEK WFKELTLHKK
     351  TPLDILLKKM SIDKKNEGSK KKVVILESIG KCYGDSAQFV SDEDLRFILT
     401  DETLVYPFKD IPADQQKVVI PPGSKSISNR ALILAALGEG QCKIKNLLHS
     451  DDTKHMLTAV HELKGATISW EDNGETVVVE GHGGSTLSAC ADPLYLGNAG
     501  TASRFLTSLA ALVNSTSSQK YIVLTGNARM QQRPIAPLVD SLRANGTKIE
     551  YLNNEGSLPI KVYTDSVFKG GRIELAATVS SQYVSSILMC APYAEEPVTL
     601  ALVGGKPISK LYVDMTIKMM EKFGINVETS TTEPYTYYIP KGHYINPSEY
     651  VIESDASSAT YPLAFAAMTG TTVTVPNIGF ESLQGDARFA RDVLKPMGCK
     701  ITQTATSTTV SGPPVGTLKP LKHVDMEPMT DAFLTACVVA AISHDSDPNS
     751  ANTTTIEGIA NQRVKECNRI LAMATELAKF GVKTTELPDG IQVHGLNSIK
     801  DLKVPSDSSG PVGVCTYDDH RVAMSFSLLA GMVNSQNERD EVANPVRILE
     851  RHCTGKTWPG WWDVLHSELG AKLDGAEPLE CTSKKNSKKS VVIIGMRAAG
     901  KTTISKWCAS ALGYKLVDLD ELFEQQHNNQ SVKQFVVENG WEKFREEETR
     951  IFKEVIQNYG DDGYVFSTGG GIVESAESRK ALKDFASSGG YVLHLHRDIE
    1001  ETIVFLQSDP SRPAYVEEIR EVWNRREGWY KECSNFSFFA PHCSAEAEFQ
    1051  ALRRSFSKYI ATITGVREIE IPSGRSAFVC LTFDDLTEQT ENLTPICYGC
    1101  EAVEVRVDHL ANYSADFVSK QLSILRKATD SIPIIFTVRT MKQGGNFPDE
    1151  EFKTLRELYD IALKNGVEFL DLELTLPTDI QYEVINKRGN TKIIGSHHDF
    1201  QGLYSWDDAE WENRFNQALT LDVDVVKFVG TAVNFEDNLR LEHFRDTHKN
    1251  KPLIAVNMTS KGSISRVLNN VLTPVTSDLL PNSAAPGQLT VAQINKMYTS
    1301  MGGIEPKELF VVGKPIGHSR SPILHNTGYE ILGLPHKFDK FETESAQLVK
    1351  EKLLDGNKNF GGAAVTIPLK LDIMQYMDEL TDAAKVIGAV NTVIPLGNKK
    1401  FKGDNTDWLG IRNALINNGV PEYVGHTAGL VIGAGGTSRA ALYALHSLGC
    1451  KKIFIINRTT SKLKPLIESL PSEFNIIGIE STKSIEEIKE HVGVAVSCVP
    1501  ADKPLDDELL SKLERFLVKG AHAAFVPTLL EAAYKPSVTP VMTISQDKYQ
    1551  WHVVPGSQML VHQGVAQFEK WTGFKGPFKA IFDAVTKE*

external links for Aro1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Aro1p

1)	Duncan K, et al. (1987) The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains. Biochem J 246(2):375-86
2)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41