VBA4/YDR119W Protein Information Help

Standard Name Vba4p 1
Systematic Name Ydr119wp
ORF Classification Uncharacterized
Description Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene (1, 2, 3, 4)
Name Description Vacuolar Basic Amino acid transporter 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 768
Molecular Weight (Da) 85,682
Isoelectric Point (pI) 8.23

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vba4p (InterPro)
Transmembrane Domains There are 14 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006ABA4 | Q04602
MIPS: YDR119W
NCBI: 6320324 | 74627205 | 747893 | NP_010404.1
GenBank/EMBL/DDBJ: DAA11964.1 | Z48758
External Classifications TC: 2.A.1.3 [The Drug:H+ Antiporter-2 (14 Spanner) (DHA2) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MGKKDRQRKK LREFAKLKNR QRNLRKSVQT LKNEVQREAK VPRTSNQIAL
      51  GNDKIEEINE NSPLLSAPSK QEEVSIPKAV DIDTIDAQPL HEGPKIDDSP
     101  QDEVNSIKGK PADKANEDDL KPPSQHEACG NSALQSSITD FSDRSVSPLQ
     151  SITSCNTPMS EHELPVSSSN SFERADDMPV VQADNQTSSS KSLHIVAPSP
     201  EVPVSGDEIT SYGYGSIPQS IGDVENGLNP PYVENTSSDE LVHDLTRRRI
     251  FSSCMCTYLF FIAMDSSIIL VIASKIASEF HELWRLSLVI SAYLLSNAIG
     301  QLVFLKLSLI SSVKLLLCIA QFSFILGGYL SWSSAHFWTF IFARCVTGFG
     351  GGSLIALKST IMNRFSQKND SRYSLSASMI TFAMGVVIGP FMMNLFDSSH
     401  GSGWRNAFLI PVPFCLVNAS IMLADMYSVK STLYGRPTPT LWKRFKNTLL
     451  SPDLYEILTL TLFLLCFVQV TSLDLTGLKN NTMIQALLFS VIIVCGILFF
     501  LIETSDTYMN SVISMSLQGD KRLIWTMIGI SFCFAALMCI IPFGTTYFII
     551  VLNLSTLQLA ERLSPFFFSI VLGYFSVSYF WKSKGQNFLL KFVLSGATLL
     601  LYVALMGVSL NLPVWKQYIC LSLPFLGSSM ILTLLSNLYH EYHEQRKSPI
     651  SGSIVYCFGA VGGTVGISLG GYVFHKTLIK LMHEKVMPFS KQGYLKKDLL
     701  KIIKHATESS DWVHESAPKF VFQTLIECYL QACRNVFKLS TLFFTITVVA
     751  IFIFNRIHCR SQNCLSLS*

external links for Vba4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Vba4p
1) Shimazu M, et al.  (2005) A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J Biol Chem 280(6):4851-7
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Tarassov K, et al.  (2008) An in vivo map of the yeast protein interactome. Science 320(5882):1465-70