ARX1/YDR101C Protein Information Help

Standard Name Arx1p 1
Systematic Name Ydr101cp
ORF Classification Verified
Description Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex (2, 3, 4, 5)
Name Description Associated with Ribosomal eXport complex 1
Experimental Data
Molecules/cell 45100 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 593
Molecular Weight (Da) 65,212
Isoelectric Point (pI) 7.17

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Arx1p (InterPro)
Physical Interactions There are 295 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052E3C | Q03862
MIPS: YDR101C
NCBI: 6320306 | 633637 | 74655006 | NP_010386.1
GenBank/EMBL/DDBJ: DAA11948.1 | Z47746
External Classifications EC: 3.-.-.- [Hydrolases]
Amino Acid Sequence (or in FASTA format)
 
       1  MALAISHEDT QILLKDKNIL QESVLNKYRT AGQIAQTALK YVTSLINDSY
      51  HSKTTQRQLT VPELCLLTDS FILTRLEQYY KNKVNERGIA IPTTIDIDQI
     101  SGGWCPEIDD TQNLLNWNKG KDSTFASSVT GTLRPGDLVK ITLGVHIDGY
     151  TSEVSHTMVI YPVDETKPIL QPTGPLLGGK ADAVAAAHIA METVVALLAC
     201  ALTPEKLPAS LGGTSSGITG QLIRTIVDTI ARSYNCGVVP GSRVRRIRRF
     251  LAGQNEGIVA EREYKGVVWT ESHQEADLLS NTDAKDLTVV DRGQSTPFTN
     301  VSAIPSDDFV VQSGEVYLID LKMASLEHCT KKGLVTLETV DSYTGKSHKA
     351  GELIARPGAY VRDFAQTHIL KLKTSRQLLT KIDKQGVYPF KLSHLSSNFP
     401  FVHENEEELQ SLKKDLKSFR LGMSEISNNY LCVESPIQIA RWVPWDHILK
     451  ATNPNGNLSY DATSTLTLPG HELPLPKLGV SAIKLKSLMN STKESISLPV
     501  ARECNTIVLC DSSVSTTDRP ELLRLTGGSK TCQPSWIHSQ HELNPQDSIV
     551  QGIFQLATLA KDKRFGLLLK ETQPMKQKSV ETSNGGVEET MKM*

external links for Arx1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Arx1p
1) Nissan TA, et al.  (2002) 60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. EMBO J 21(20):5539-47
2) Hung NJ and Johnson AW  (2006) Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae. Mol Cell Biol 26(10):3718-27
3) Lebreton A, et al.  (2006) A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. J Cell Biol 173(3):349-60
4) Hung NJ, et al.  (2008) Arx1 Is a Nuclear Export Receptor for the 60S Ribosomal Subunit in Yeast. Mol Biol Cell 19(2):735-44
5) Bradatsch B, et al.  (2007) Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit. Mol Cell 27(5):767-79
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41