RLI1/YDR091C Protein Information Help

Standard Name Rli1p 1
Systematic Name Ydr091cp
ORF Classification Verified
Description Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species (2, 3, 4, 5)
Name Description RNase L Inhibitor
Experimental Data
Molecules/cell 6280 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 608
Molecular Weight (Da) 68,340
Isoelectric Point (pI) 8.82

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rli1p (InterPro)
Physical Interactions There are 85 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053146 | Q03195
MIPS: YDR091C
NCBI: 377656234 | 398365537 | 51830238 | 74676343 | 914875 | NP_010376.3
GenBank/EMBL/DDBJ: DAA11938.1 | AY723776 | Z50111
Amino Acid Sequence (or in FASTA format)
 
       1  MSDKNSRIAI VSADKCKPKK CRQECKRSCP VVKTGKLCIE VTPTSKIAFI
      51  SEILCIGCGI CVKKCPFDAI QIINLPTNLE AHVTHRYSAN SFKLHRLPTP
     101  RPGQVLGLVG TNGIGKSTAL KILAGKQKPN LGRFDDPPEW QEIIKYFRGS
     151  ELQNYFTKML EDDIKAIIKP QYVDNIPRAI KGPVQKVGEL LKLRMEKSPE
     201  DVKRYIKILQ LENVLKRDIE KLSGGELQRF AIGMSCVQEA DVYMFDEPSS
     251  YLDVKQRLNA AQIIRSLLAP TKYVICVEHD LSVLDYLSDF VCIIYGVPSV
     301  YGVVTLPASV REGINIFLDG HIPAENLRFR TEALQFRIAD ATEDLQNDSA
     351  SRAFSYPSLK KTQGDFVLNV EEGEFSDSEI LVMMGENGTG KTTLIKLLAG
     401  ALKPDEGQDI PKLNVSMKPQ KIAPKFPGTV RQLFFKKIRG QFLNPQFQTD
     451  VVKPLRIDDI IDQEVQHLSG GELQRVAIVL ALGIPADIYL IDEPSAYLDS
     501  EQRIICSKVI RRFILHNKKT AFIVEHDFIM ATYLADKVIV FEGIPSKNAH
     551  ARAPESLLTG CNRFLKNLNV TFRRDPNSFR PRINKLDSQM DKEQKSSGNY
     601  FFLDNTGI*

external links for Rli1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rli1p
1) Rutkowski, L.H. and R.E. Esposito  (1999) personal communication
2) Dong J, et al.  (2004) The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem 279(40):42157-68
3) Kispal G, et al.  (2005) Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J 24(3):589-98
4) Khoshnevis S, et al.  (2010) The iron-sulphur protein RNase L inhibitor functions in translation termination. EMBO Rep 11(3):214-9
5) Zhai C, et al.  (2013) The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome.LID - 10.1038/onc.2012.604 [doi] Oncogene ()
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41