STN1/YDR082W Protein Information

Standard Name	Stn1p 1
Systematic Name	Ydr082wp
ORF Classification	Verified
Description	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping (2)
Name Description	Suppressor of cdc ThirteeN 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	494
Molecular Weight (Da)	57,510
Isoelectric Point (pI)	5.46

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Stn1p (InterPro)
Physical Interactions	There are 41 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000136117 \| P38960 MIPS: YDR082W NCBI: 1431553 \| 2183246 \| 262118720 \| 281500902 \| 51830234 \| 558253 \| 577809 \| 6320287 \| 731365 \| NP_010367.1 GenBank/EMBL/DDBJ: DAA11929.1 \| AF002132 \| AY723774 \| X82086 \| Z46796 \| Z74378

Amino Acid Sequence (or in FASTA format)
1 MDKYGHIAHQ EGDVCYYIPR LFKYNSYYSG TEDVRIFVGD LKYRMRVSLQ 51 ICEKYYDRRL SMLFWKNHPL QQIHLIGCII GLQFKWIGKQ EYIFFQLDDC 101 TSDSSLVGYT SDMRFLTCKV KKDSILSWGL NITDLIGLTL HVYGQASLNY 151 QELQVEYLRL CYSLTEEIDH WKITMNMREQ LDTPWSLSDF VIGELFTQEQ 201 EWTPETSQIE VVNPDFVGIG YKTPESKRNE TTFIEQLQEE RLKDELEIIS 251 PYNSTDTSNS VHSLSFRFVS SLKDFPETHF LNSGDQIDNG NDEQLKKLEY 301 QSANLPVMIP NRTSAKSNLM LILLGLQMKE ISNSDLYKLK EVRSVVTSLA 351 SFLFQQQNVG VMKSFDSLEK EAFRDLVNRL VSQGLIGLKD KTSETFDLLP 401 LKNLFEYAEK RISVLMKLQC YTGTVQLSHV QEKLHLPYIT TNGIVDVFKE 451 CLKRTKKQYP EVLKNWWIDL DPKNGMEDQN SGILLHLEYA AAYS*

Amino Acid Sequence (or in FASTA format)

       1  MDKYGHIAHQ EGDVCYYIPR LFKYNSYYSG TEDVRIFVGD LKYRMRVSLQ
      51  ICEKYYDRRL SMLFWKNHPL QQIHLIGCII GLQFKWIGKQ EYIFFQLDDC
     101  TSDSSLVGYT SDMRFLTCKV KKDSILSWGL NITDLIGLTL HVYGQASLNY
     151  QELQVEYLRL CYSLTEEIDH WKITMNMREQ LDTPWSLSDF VIGELFTQEQ
     201  EWTPETSQIE VVNPDFVGIG YKTPESKRNE TTFIEQLQEE RLKDELEIIS
     251  PYNSTDTSNS VHSLSFRFVS SLKDFPETHF LNSGDQIDNG NDEQLKKLEY
     301  QSANLPVMIP NRTSAKSNLM LILLGLQMKE ISNSDLYKLK EVRSVVTSLA
     351  SFLFQQQNVG VMKSFDSLEK EAFRDLVNRL VSQGLIGLKD KTSETFDLLP
     401  LKNLFEYAEK RISVLMKLQC YTGTVQLSHV QEKLHLPYIT TNGIVDVFKE
     451  CLKRTKKQYP EVLKNWWIDL DPKNGMEDQN SGILLHLEYA AAYS*

external links for Stn1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Stn1p

1)	Grandin N, et al. (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev 11(4):512-27
2)	Grossi S, et al. (2004) Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev 18(9):992-1006