VPS41/YDR080W Protein Information

Standard Name	Vps41p 1
Systematic Name	Ydr080wp
Alias	Cvt8p , Fet2p , Svl2p 2 , Vam2p 3 , Vpl20p 1
ORF Classification	Verified
Description	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport (4, 5, 6)
Name Description	Vacuolar Protein Sorting 1

Experimental Data
Molecules/cell	1170 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	992
Molecular Weight (Da)	113,411
Isoelectric Point (pI)	4.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Vps41p (InterPro)
Physical Interactions	There are 116 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FFF \| P38959 MIPS: YDR080W NCBI: 1431549 \| 1845525 \| 2506925 \| 398365475 \| 558251 \| 577807 \| NP_010365.3 GenBank/EMBL/DDBJ: DAA11927.1 \| AB000223 \| X82086 \| Z46796 \| Z74376

Amino Acid Sequence (or in FASTA format)
1 MTTDNHQNDS VLDQQSGERT IDESNSISDE NNVDNKREDV NVTSPTKSVS 51 CISQAENGVA SRTDESTITG SATDAETGDD DDDDDDDDDE DEDDEDEPPL 101 LKYTRISQLP KNFFQRDSIS SCLFGDTFFA FGTHSGILHL TTCAFEPIKT 151 IKCHRSSILC INTDGKYFAT GSIDGTVIIG SMDDPQNITQ YDFKRPINSV 201 ALHSNFQASR MFVSGGMAGD VVLSQRNWLG NRIDIVLNKK KKKKTRKDDL 251 SSDMKGPIMG IYTMGDLILW MDDDGITFCD VPTRSQLLNI PFPSRIFNVQ 301 DVRPDLFRPH VHFLESDRVV IGWGSNIWLF KVSFTKDSNS IKSGDSNSQS 351 NNMSHFNPTT NIGSLLSSAA SSFRGTPDKK VELECHFTVS MLITGLASFK 401 DDQLLCLGFD IDIEEEATID EDMKEGKNFS KRPENLLAKG NAPELKIVDL 451 FNGDEIYNDE VIMKNYEKLS INDYHLGKHI DKTTPEYYLI SSNDAIRVQE 501 LSLKDHFDWF MERKQYYKAW KIGKYVIGSE ERFSIGLKFL NSLVTKKDWG 551 TLVDHLNIIF EETLNSLDSN SYDVTQNVLK EWADIIEILI TSGNIVEIAP 601 LIPKKPALRK SVYDDVLHYF LANDMINKFH EYITKWDLKL FSVEDFEEEL 651 ETRIEAASEP TASSKEEGSN ITYRTELVHL YLKENKYTKA IPHLLKAKDL 701 RALTIIKIQN LLPQYLDQIV DIILLPYKGE ISHISKLSIF EIQTIFNKPI 751 DLLFENRHTI SVARIYEIFE HDCPKSFKKI LFCYLIKFLD TDDSFMISPY 801 ENQLIELYSE YDRQSLLPFL QKHNNYNVES AIEVCSSKLG LYNELIYLWG 851 KIGETKKALS LIIDELKNPQ LAIDFVKNWG DSELWEFMIN YSLDKPNFTK 901 AILTCSDETS EIYLKVIRGM SDDLQIDNLQ DIIKHIVQEN SLSLEVRDNI 951 LVIINDETKK FANEFLKIRS QGKLFQVDES DIEINDDLNG VL*

Amino Acid Sequence (or in FASTA format)

       1  MTTDNHQNDS VLDQQSGERT IDESNSISDE NNVDNKREDV NVTSPTKSVS
      51  CISQAENGVA SRTDESTITG SATDAETGDD DDDDDDDDDE DEDDEDEPPL
     101  LKYTRISQLP KNFFQRDSIS SCLFGDTFFA FGTHSGILHL TTCAFEPIKT
     151  IKCHRSSILC INTDGKYFAT GSIDGTVIIG SMDDPQNITQ YDFKRPINSV
     201  ALHSNFQASR MFVSGGMAGD VVLSQRNWLG NRIDIVLNKK KKKKTRKDDL
     251  SSDMKGPIMG IYTMGDLILW MDDDGITFCD VPTRSQLLNI PFPSRIFNVQ
     301  DVRPDLFRPH VHFLESDRVV IGWGSNIWLF KVSFTKDSNS IKSGDSNSQS
     351  NNMSHFNPTT NIGSLLSSAA SSFRGTPDKK VELECHFTVS MLITGLASFK
     401  DDQLLCLGFD IDIEEEATID EDMKEGKNFS KRPENLLAKG NAPELKIVDL
     451  FNGDEIYNDE VIMKNYEKLS INDYHLGKHI DKTTPEYYLI SSNDAIRVQE
     501  LSLKDHFDWF MERKQYYKAW KIGKYVIGSE ERFSIGLKFL NSLVTKKDWG
     551  TLVDHLNIIF EETLNSLDSN SYDVTQNVLK EWADIIEILI TSGNIVEIAP
     601  LIPKKPALRK SVYDDVLHYF LANDMINKFH EYITKWDLKL FSVEDFEEEL
     651  ETRIEAASEP TASSKEEGSN ITYRTELVHL YLKENKYTKA IPHLLKAKDL
     701  RALTIIKIQN LLPQYLDQIV DIILLPYKGE ISHISKLSIF EIQTIFNKPI
     751  DLLFENRHTI SVARIYEIFE HDCPKSFKKI LFCYLIKFLD TDDSFMISPY
     801  ENQLIELYSE YDRQSLLPFL QKHNNYNVES AIEVCSSKLG LYNELIYLWG
     851  KIGETKKALS LIIDELKNPQ LAIDFVKNWG DSELWEFMIN YSLDKPNFTK
     901  AILTCSDETS EIYLKVIRGM SDDLQIDNLQ DIIKHIVQEN SLSLEVRDNI
     951  LVIINDETKK FANEFLKIRS QGKLFQVDES DIEINDDLNG VL*

external links for Vps41p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Vps41p

1)	Raymond CK, et al. (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402
2)	Zheng B, et al. (1998) Isolation of yeast mutants defective for localization of vacuolar vital dyes. Proc Natl Acad Sci U S A 95(20):11721-6
3)	Wada Y, et al. (1992) Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants. J Biol Chem 267(26):18665-70
4)	Seals DF, et al. (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7
5)	Cowles CR, et al. (1997) Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. EMBO J 16(10):2769-82
6)	Nakamura N, et al. (1997) Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J Biol Chem 272(17):11344-9
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41