OCA6/YDR067C Protein Information

Standard Name	Oca6p 1, 2
Systematic Name	Ydr067cp
ORF Classification	Uncharacterized
Description	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT (3, 4, 5)
Name Description	Oxidant-induced Cell-cycle Arrest 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	224
Molecular Weight (Da)	26,024
Isoelectric Point (pI)	9.53

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Oca6p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006AEF0 \| Q12454 MIPS: YDR067C NCBI: 1431523 \| 45270872 \| 6320272 \| 706833 \| 74676603 \| 798918 \| NP_010352.1 GenBank/EMBL/DDBJ: DAA11913.1 \| AY558491 \| X84162 \| Z49209 \| Z74363
External Classifications	EC: 3.1.3.48 [Protein-tyrosine-phosphatase]

Amino Acid Sequence (or in FASTA format)
1 MTLVTPLQFS TVQPNLYRGS YPREINLPFL RTLRLKYILS LTPEPLSTDP 51 LMVKFCEENN IKTIHIKCQS ERKADKTKPK IKRKKKTVPI EYDVVVRCVK 101 FLIDKGHYPC YMHCTNGELI ISLVVACMRK FSYWSTVSIL NEFLVYNSSI 151 NIHERNFIEN FNSEIEVDDL DIKDKVPWIT VRYIARTATE SKDELRVDDA 201 NASEKVARVS SVSNSLPKLK FHSM*

Amino Acid Sequence (or in FASTA format)

       1  MTLVTPLQFS TVQPNLYRGS YPREINLPFL RTLRLKYILS LTPEPLSTDP
      51  LMVKFCEENN IKTIHIKCQS ERKADKTKPK IKRKKKTVPI EYDVVVRCVK
     101  FLIDKGHYPC YMHCTNGELI ISLVVACMRK FSYWSTVSIL NEFLVYNSSI
     151  NIHERNFIEN FNSEIEVDDL DIKDKVPWIT VRYIARTATE SKDELRVDDA
     201  NASEKVARVS SVSNSLPKLK FHSM*

external links for Oca6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Oca6p

1)	Warringer, J, et al. (2006) personal communication
2)	Addinall SG, et al. (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Kushner DB, et al. (2003) Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Proc Natl Acad Sci U S A 100(26):15764-9
5)	Tan SX, et al. (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20(5):1493-508