RTR2/YDR066C Protein Information

Standard Name	Rtr2p 1
Systematic Name	Ydr066cp
ORF Classification	Verified
Description	Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Regulator of TRanscription 1

Experimental Data
Molecules/cell	1050 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	196
Molecular Weight (Da)	22,541
Isoelectric Point (pI)	4.78

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rtr2p (InterPro)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A047 \| Q12378 MIPS: YDR066C NCBI: 1431521 \| 6320271 \| 706832 \| 74676590 \| 798917 \| NP_010351.1 GenBank/EMBL/DDBJ: DAA11912.1 \| X84162 \| Z49209 \| Z74362
External Classifications	EC: 3.1.3.16 [Phosphoprotein phosphatase]

Amino Acid Sequence (or in FASTA format)
1 MQIITTTFIQ KVILGSHQLH EQLSIVEARM IESAIVSMLT ESFCENEQTL 51 KYLARLLSPM SYMDVINARR GKKICGYPLC YKSAAENSSD GFFIHSMYCN 101 NYHSKCSLYL MRQLSQTPLH ERRGVHLTSY INLEFDDMYS VSLLEELVGS 151 EVPIDTVKSL ITSFKDLEFD DTYKNEPLPL DVYFGQLTTD EETCIE*

Amino Acid Sequence (or in FASTA format)

       1  MQIITTTFIQ KVILGSHQLH EQLSIVEARM IESAIVSMLT ESFCENEQTL
      51  KYLARLLSPM SYMDVINARR GKKICGYPLC YKSAAENSSD GFFIHSMYCN
     101  NYHSKCSLYL MRQLSQTPLH ERRGVHLTSY INLEFDDMYS VSLLEELVGS
     151  EVPIDTVKSL ITSFKDLEFD DTYKNEPLPL DVYFGQLTTD EETCIE*

external links for Rtr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rtr2p

1)	Gibney PA, et al. (2008) Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryot Cell 7(6):938-48
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41