MAK21/YDR060W Protein Information Help

Standard Name Mak21p
Systematic Name Ydr060wp
Alias Noc1p 1
ORF Classification Verified
Description Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein (2, 3)
Name Description MAintenance of Killer 4
Experimental Data
Molecules/cell 15000 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,025
Molecular Weight (Da) 116,675
Isoelectric Point (pI) 4.72

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mak21p (InterPro)
Physical Interactions There are 257 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053111 | Q12176
MIPS: YDR060W
NCBI: 1431509 | 398365319 | 6225679 | 706826 | 798911 | NP_010345.3 | NM_001180368.3
GenBank/EMBL/DDBJ: DAA11906.1 | X84162 | Z49209 | Z74356
Amino Acid Sequence (or in FASTA format)
 
       1  MSENNGNPLD LSSLRNKISS KLRDNNSKKA KKTHKGKDVK ASSNSKKVNE
      51  DIRREALALG ASEEDLKLIQ GLSDDDDAKS EQEFDAVADE DADDKGFKND
     101  LQNFMKNVGF DQHKLEDVDD DDIEEESTSS KESKIPAQEK EHAQSNIASS
     151  TIEKTSQESI DNGSEQEENT VEEANLSSDQ EPESESAEKE KKEEKDGGLI
     201  TQTTIISSDK LIIPYDKPWY EIPLDPQVGQ NDDVEELSKE QIEKLFERGK
     251  QTLEADNQTY YEEFTKDSSQ AKFMSQILSD GTLNDKISAV TLLIQDSPLH
     301  NTKSLETLVS YCGKKSRNSA LQSLNALKDL FLNGLLPNRK LRYFKNQPGL
     351  SMMLNKKTLA IFYFEDYLKK LFFRVLEVLE VLSHDPIIHV RLQILNHVFD
     401  LLTNQPEQEF NLLRLGVNKI GDIDSKVSSK ASYLLLKLEQ AHPNMKSIVI
     451  DAIVDIALRP NADYHTTYYS VITLNQTILK RSEDSVANKL VKTYFTLFEK
     501  FLINTDKDNT NGVVKSNSKS YEEKRKKNFK KGKHGGKSVK IEKTENEVLD
     551  EKNSKLFSAL LTGINRAFPF AQIPASVYEV HMETLFKITH SSNFNTSIQA
     601  LVLINQVTVK AKLNSDRYYR TLYESLFDPR LVNSSKQGIY LNLLYKSLKQ
     651  DALNVERVEA FVKRILQVCS HWLNVGTITG FFFLLIQLAK TVPQIKNLLT
     701  NTPVDYEYES DAEEEQGDKD IKRKEYDGRK RDPKFANAEK SSLWEINNFI
     751  NHFHPTVKTY ANAYVTGETE QIAKPDLGLF TLSHFLDRFV YRSAKQTNTA
     801  RGTSIMQPLF SGSRVNDSVL VKASDIMHDQ GPVNTEDWLT KKVEDIKPED
     851  KFFYQYFTTK KTADGKGKKS NKASNFDSDD EMDENEIWSA LVKSRPDVED
     901  DSDDSELDFA EDDFSDSTSD DEPKLDAIDD EDAKSEGSQE SDQEEGLDED
     951  IFYSFDGEQD NSDKKRSFAE SSEEDESSEE EKEEEENKEV SAKRAKKKQR
    1001  KNMLKSLPVF ASADDYAQYL DQDSD*

external links for Mak21p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Mak21p
1) Milkereit P, et al.  (2001) Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell 105(4):499-509
2) Edskes HK, et al.  (1998) Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. J Biol Chem 273(44):28912-20
3) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4) Wickner RB  (1974) Chromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae. Genetics 76(3):423-32
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41