VMS1/YDR049W Protein Information Help

Standard Name Vms1p 1
Systematic Name Ydr049wp
ORF Classification Verified
Description Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans (1, 2, 3)
Name Description VCP/Cdc48-associated Mitochondrial Stress-responsive 1
Experimental Data
Molecules/cell 3930 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 632
Molecular Weight (Da) 72,733
Isoelectric Point (pI) 9.64

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vms1p (InterPro)
Physical Interactions There are 24 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053189 | Q04311
MIPS: YDR049W
NCBI: 51830226 | 6320253 | 74627200 | 798901 | NP_010334.1
GenBank/EMBL/DDBJ: DAA11896.1 | AY723770 | Z49209
Amino Acid Sequence (or in FASTA format)
 
       1  MNSQKASKMT GSLKKNDLYI FDLSEQLLNS LKLMSFDSTL REVEVEKTSD
      51  NDRNKESGDL QIARKKVTSN VMRCSVCQMS FDSRNEQKAH YQTDYHLMNV
     101  KRNLRGLDIL SVEEFDALIS KEHGIKSEDE NSGGEQTSSD HEESEEASDR
     151  DPDLQTNNYM ETIIENDLQK LGFQKDESDA ISHINTQSPY IYFKSKYLQK
     201  NEVLAIYKSL FNKRSLSNPN EALTFWNSQE NPMAISALFM VGGGHFAGAI
     251  VSHQRLNVKG NAHKKDETLI EQAVNFLEHK TFHRYTTRRK QGGSQSAMDN
     301  AKGKANSAGS ALRRYNESAL KTDIQGVLKD WEPYLSKCDN IFIRARNVSD
     351  KKIFTDNTVL NKGDERIKSF PFTTNRPTVL ELKKAWCELS YLKILPKPEP
     401  LAVKETVQKL EVSNKKDEFK EKQEPLLEEI QTEEIISLLK KGRAPLLISF
     451  LKKNKLDGNF RLKPESKYSL TPTMLHYASQ QGMKQMALIL LSNIKCDPTI
     501  KNRLGRTAWD LNRNDDVRHA FQIARYNLGE SFTNWDETHI GQPLSREQVD
     551  EINEKKKAIE NEKAEKLIKL ELEAAKEKQR FAKDAERGPG KKLTNIPSIQ
     601  QQNLNSLTDE QRRRLMREQR ARAAEERMKK KY*

external links for Vms1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Vms1p
1) Heo JM, et al.  (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80
2) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
3) Tran JR, et al.  (2011) A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem 286(7):5744-55
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41