ENA2/YDR039C Protein Information Help

Standard Name Ena2p 1
Systematic Name Ydr039cp
ORF Classification Verified
Description P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux (1, 2)
Name Description Exitus NAtru (Latin, "exit sodium") 1
Experimental Data
Molecules/cell 639 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,091
Molecular Weight (Da) 120,316
Isoelectric Point (pI) 5.28

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ena2p (InterPro)
Transmembrane Domains There are 10 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012628F | Q01896
MIPS: YDR039C
NCBI: 1431488 | 398365207 | 416667 | 5513 | 790262 | 976129 | NP_010324.3
GenBank/EMBL/DDBJ: DAA11887.1 | U24069 | X67136 | Z54075 | Z74335
External Classifications EC: 3.6.3.12 [Potassium-transporting ATPase]
EC: 3.6.3.7 [Sodium-exporting ATPase] TC: 3.A.3.9 [The Na+ Efflux-ATPase (ENa) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MSEGTVKENN NEEFNAYHTL TTEEAAEFIG TSLTEGLTQD ESLRRLKAVG
      51  ENTLGDDTKI DYKAMVLHQV CNAMIMVLVI SMAISFAVRD WITGGVISFV
     101  IAVNVLIGLV QEYKATKTMN SLKNLSSPNA HVIRNGKSET INSKDVVPGD
     151  ICLVKVGDTI PADLRLIETK NFDTDESLLT GESLPVSKDA NLVFGKEEET
     201  SVGDRLNLAF SSSAVVKGRA KGIVIKTALN SEIGKIAKSL QGDSGLISRD
     251  PSKSWLQNTW ISTKKVTGAF LGTNVGTPLH RKLSKLAVLL FWIAVLFAII
     301  VMASQKFDVD KRVAIYAICV ALSMIPSSLV VVLTITMSVG AAVMVSRNVI
     351  VRKLDSLEAL GAVNDICSDK TGTLTQGKML ARQIWIPRFG TITISNSDDP
     401  FNPNEGNVSL IPRFSPYEYS HNEDGDVGIL QNFKDRLYEK DLPEDIDMDL
     451  FQKWLETATL ANIATVFKDD ATDCWKAHGD PTEIAIQVFA TKMDLPHNAL
     501  TGEKSTNQSN ENDQSSLSQH NEKPGSAQFE HIAEFPFDST VKRMSSVYYN
     551  NHNETYNIYG KGAFESIISC CSSWYGKDGV KITPLTDCDV ETIRKNVYSL
     601  SNEGLRVLGF ASKSFTKDQV NDDQLKNITS NRATAESDLV FLGLIGIYDP
     651  PRNETAGAVK KFHQAGINVH MLTGDFVGTA KAIAQEVGIL PTNLYHYSQE
     701  IVDSMVMTGS QFDGLSEEEV DDLPVLPLVI ARCSPQTKVR MIEALHRRKK
     751  FCAMTGDGVN DSPSLKMANV GIAMGINGSD VSKEASDIVL SDDNFASILN
     801  AVEEGRRMTD NIQKFVLQLL AENVAQALYL IIGLVFRDEN GKSVFPLSPV
     851  EVLWIIVVTS CFPAMGLGLE KAAPDLMDRP PHDSEVGIFT WEVIIDTFAY
     901  GIIMTGSCMA SFTGSLYGIN SGRLGHDCDG TYNSSCRDVY RSRSAAFATM
     951  TWCALILAWE VVDMRRSFFR MHPDTDSPVK EFFRSIWGNQ FLFWSIIFGF
    1001  VSAFPVVYIP VINDKVFLHK PIGAEWGLAI AFTIAFWIGA ELYKCGKRRY
    1051  FKTQRAHNPE NDLESNNKRD PFEAYSTSTT IHTEVNIGIK Q*

external links for Ena2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome TCDB
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ena2p
1) Haro R, et al.  (1991) A novel P-type ATPase from yeast involved in sodium transport. FEBS Lett 291(2):189-91
2) Garciadeblas B, et al.  (1993) Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae. Mol Gen Genet 236(2-3):363-8
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41