ARO3/YDR035W Protein Information Help

Standard Name Aro3p
Systematic Name Ydr035wp
ORF Classification Verified
Description 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan (1, 2, 3)
Name Description AROmatic amino acid requiring
Experimental Data
Molecules/cell 8970 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 370
Molecular Weight (Da) 41,070
Isoelectric Point (pI) 7.35

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Aro3p (InterPro)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012600C | P14843
MIPS: YDR035W
NCBI: 1122357 | 114194 | 1431480 | 3383 | 398365167 | 45269207 | NP_010320.3 | NM_001180343.3
GenBank/EMBL/DDBJ: AAS55983.1 | CAA31865.1 | CAA92374.1 | CAA98859.1 | DAA11883.1 | AY557657 | X13514 | Z68196 | Z74331
External Classifications EC: 2.5.1.54 [3-deoxy-7-phosphoheptulonate synthase]
Amino Acid Sequence (or in FASTA format)
       1  MFIKNDHAGD RKRLEDWRIK GYDPLTPPDL LQHEFPISAK GEENIIKARD
      51  SVCDILNGKD DRLVIVIGPC SLHDPKAAYD YADRLAKISE KLSKDLLIIM
     101  RAYLEKPRTT VGWKGLINDP DMNNSFQINK GLRISREMFI KLVEKLPIAG
     151  EMLDTISPQF LSDCFSLGAI GARTTESQLH RELASGLSFP IGFKNGTDGG
     201  LQVAIDAMRA AAHEHYFLSV TKPGVTAIVG TEGNKDTFLI LRGGKNGTNF
     251  DKESVQNTKK QLEKAGLTDD SQKRIMIDCS HGNSNKDFKN QPKVAKCIYD
     301  QLTEGENSLC GVMIESNINE GRQDIPKEGG REGLKYGCSV TDACIGWEST
     351  EQVLELLAEG VRNRRKALKK *                               

external links for Aro3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB GeneMANIA YeastRC Structure Prediction (Seattle)
YOGY IMP

References cited on this page View Complete Literature Guide for Aro3p
1) Paravicini G, et al.  (1988) Structure of the ARO3 gene of Saccharomyces cerevisiae. Mol Gen Genet 214(1):165-9
2) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
3) Helmstaedt K, et al.  (2005) Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 102(28):9784-9
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41