ARO3/YDR035W Protein Information

Standard Name	Aro3p
Systematic Name	Ydr035wp
ORF Classification	Verified
Description	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan (1, 2, 3)
Name Description	AROmatic amino acid requiring

Experimental Data
Molecules/cell	8970 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	370
Molecular Weight (Da)	41,070
Isoelectric Point (pI)	7.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aro3p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012600C \| P14843 MIPS: YDR035W NCBI: 1122357 \| 114194 \| 1431480 \| 3383 \| 398365167 \| 45269207 \| NP_010320.3 GenBank/EMBL/DDBJ: DAA11883.1 \| AY557657 \| X13514 \| Z68196 \| Z74331
External Classifications	EC: 2.5.1.54 [3-deoxy-7-phosphoheptulonate synthase]

Amino Acid Sequence (or in FASTA format)
1 MFIKNDHAGD RKRLEDWRIK GYDPLTPPDL LQHEFPISAK GEENIIKARD 51 SVCDILNGKD DRLVIVIGPC SLHDPKAAYD YADRLAKISE KLSKDLLIIM 101 RAYLEKPRTT VGWKGLINDP DMNNSFQINK GLRISREMFI KLVEKLPIAG 151 EMLDTISPQF LSDCFSLGAI GARTTESQLH RELASGLSFP IGFKNGTDGG 201 LQVAIDAMRA AAHEHYFLSV TKPGVTAIVG TEGNKDTFLI LRGGKNGTNF 251 DKESVQNTKK QLEKAGLTDD SQKRIMIDCS HGNSNKDFKN QPKVAKCIYD 301 QLTEGENSLC GVMIESNINE GRQDIPKEGG REGLKYGCSV TDACIGWEST 351 EQVLELLAEG VRNRRKALKK *

Amino Acid Sequence (or in FASTA format)

       1  MFIKNDHAGD RKRLEDWRIK GYDPLTPPDL LQHEFPISAK GEENIIKARD
      51  SVCDILNGKD DRLVIVIGPC SLHDPKAAYD YADRLAKISE KLSKDLLIIM
     101  RAYLEKPRTT VGWKGLINDP DMNNSFQINK GLRISREMFI KLVEKLPIAG
     151  EMLDTISPQF LSDCFSLGAI GARTTESQLH RELASGLSFP IGFKNGTDGG
     201  LQVAIDAMRA AAHEHYFLSV TKPGVTAIVG TEGNKDTFLI LRGGKNGTNF
     251  DKESVQNTKK QLEKAGLTDD SQKRIMIDCS HGNSNKDFKN QPKVAKCIYD
     301  QLTEGENSLC GVMIESNINE GRQDIPKEGG REGLKYGCSV TDACIGWEST
     351  EQVLELLAEG VRNRRKALKK *

external links for Aro3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Aro3p

1)	Paravicini G, et al. (1988) Structure of the ARO3 gene of Saccharomyces cerevisiae. Mol Gen Genet 214(1):165-9
2)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
3)	Helmstaedt K, et al. (2005) Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 102(28):9784-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41