LYS14/YDR034C Protein Information Help

Standard Name Lys14p 1
Systematic Name Ydr034cp
ORF Classification Verified
Description Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer (2, 3, 4, 5)
Name Description LYSine requiring
Experimental Data
Molecules/cell 450 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 790
Molecular Weight (Da) 89,396
Isoelectric Point (pI) 6.92

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Lys14p (InterPro)
Physical Interactions There are 6 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012EA1B | P40971
MIPS: YDR034C
NCBI: 1122354 | 1431476 | 1708888 | 398365129 | 51830222 | 551278 | NP_010317.3
GenBank/EMBL/DDBJ: DAA11878.1 | AY723768 | X77361 | Z68196 | Z74330
Amino Acid Sequence (or in FASTA format)
 
       1  MFESVNLDEN SPEDRELAKV LSPPGSYLSP ASLDSGSSFT NSGTSTSCFE
      51  PKNNLPSLSF LNARAGSLGG IFNHKQMTSP SNSNIGGENV ESTTSSNDGS
     101  NENAGHPTTS EQDQNADHPT ISQADDNGHS SLTPNPAVTS TVTDKKGNTV
     151  KRKYSRNGCS ECKRRRMKCD ETKPTCWQCA RLNRQCVYVL NPKNKKRRTS
     201  NAQRVKEFRK HSTSLDNDHN NARKRQHSSC KAEKKKKVRQ NLSEDTTDPK
     251  PITDNGKNVP LDEIESLEIP NLDLTTTMNG YDVNLLMQNL NDMVNMKLHD
     301  SYLLNEELKG LDLPDLDIPE LLPASNVNSS VPISFLVNNV ITFNTKLSSF
     351  KLGGIHDKYL KIFYYDCLDS IAPFFQNQGN PLRDILLSFA KNEAYLLSSI
     401  LATGASIAYR KSNNLEDERN YCAYLSHCLS LLGEQFKNES NVLNRIEPII
     451  LTVIMLAWDC IYSMNSQWRS HLKGVTDLFK KINAGNSSKV LNVAKCWFKV
     501  METFASISTV FGGSLIDNND LDAIFDPYDY QYVDSLKFLN IMTPLNEFNL
     551  LRGHKEDFDL VIKEVFKSLN TIRSTEKNYF SKEEGLFTKK LDYLLLSSQT
     601  SSEKSKDQIS YFNTQKILVE IDKQLDYEFI DKSGIIPSDN QSHPRISNIH
     651  DNAIDMVTLK NGEEVAISWY DISHQTQVLS FLLIVLLKLL GMPKESSTIQ
     701  QVVKKIMSFF KFLDSDSPPQ NSRTCYSNFA VLIAGLNAMD EETRAIVKRY
     751  YKINGGKFQK LTEHNLNRLE KVWYGKNQNY RLEEQDVLTW *

external links for Lys14p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Lys14p
1) Contopoulou, C.R.  (1989) Personal Communication, Mortimer Map Edition 10
2) Becker B, et al.  (1998) A nonameric core sequence is required upstream of the LYS genes of Saccharomyces cerevisiae for Lys14p-mediated activation and apparent repression by lysine. Mol Microbiol 29(1):151-63
3) Feller A, et al.  (1994) Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation. Mol Cell Biol 14(10):6411-8
4) Ramos F, et al.  (1988) Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14. Eur J Biochem 171(1-2):171-6
5) El Alami M, et al.  (2002) The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector. Mol Microbiol 43(6):1629-39
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41