FAL1/YDR021W Protein Information

Standard Name	Fal1p
Systematic Name	Ydr021wp
ORF Classification	Verified
Description	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases (1, 2)
Name Description	eukaryotic translation initiation factor Four A Like

Experimental Data
Molecules/cell	3090 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	399
Molecular Weight (Da)	45,213
Isoelectric Point (pI)	9.68

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fal1p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053259 \| Q12099 MIPS: YDR021W NCBI: 1216228 \| 1431450 \| 2500524 \| 398365053 \| 51830220 \| 840874 \| NP_010304.3 GenBank/EMBL/DDBJ: DAA11867.1 \| AY723767 \| X95966 \| Z49770 \| Z74317
External Classifications	EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]

Amino Acid Sequence (or in FASTA format)
1 MSFDREEDQK LKFKTSKKLK VSSTFESMNL KDDLLRGIYS YGFEAPSSIQ 51 SRAITQIISG KDVIAQAQSG TGKTATFTIG LLQAIDLRKK DLQALILSPT 101 RELASQIGQV VKNLGDYMNV NAFAITGGKT LKDDLKKMQK HGCQAVSGTP 151 GRVLDMIKKQ MLQTRNVQML VLDEADELLS ETLGFKQQIY DIFAKLPKNC 201 QVVVVSATMN KDILEVTRKF MNDPVKILVK RDEISLEGIK QYVVNVDKEE 251 WKFDTLCDIY DSLTITQCVI FCNTKKKVDW LSQRLIQSNF AVVSMHGDMK 301 QEERDKVMND FRTGHSRVLI STDVWARGID VQQVSLVINY DLPEIIENYI 351 HRIGRSGRFG RKGVAINFIT KADLAKLREI EKFYSIKINP MPANFAELS*

Amino Acid Sequence (or in FASTA format)

       1  MSFDREEDQK LKFKTSKKLK VSSTFESMNL KDDLLRGIYS YGFEAPSSIQ
      51  SRAITQIISG KDVIAQAQSG TGKTATFTIG LLQAIDLRKK DLQALILSPT
     101  RELASQIGQV VKNLGDYMNV NAFAITGGKT LKDDLKKMQK HGCQAVSGTP
     151  GRVLDMIKKQ MLQTRNVQML VLDEADELLS ETLGFKQQIY DIFAKLPKNC
     201  QVVVVSATMN KDILEVTRKF MNDPVKILVK RDEISLEGIK QYVVNVDKEE
     251  WKFDTLCDIY DSLTITQCVI FCNTKKKVDW LSQRLIQSNF AVVSMHGDMK
     301  QEERDKVMND FRTGHSRVLI STDVWARGID VQQVSLVINY DLPEIIENYI
     351  HRIGRSGRFG RKGVAINFIT KADLAKLREI EKFYSIKINP MPANFAELS*

external links for Fal1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Fal1p

1)	Wiederkehr T, et al. (1998) Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. RNA 4(11):1357-72
2)	Kressler D, et al. (1997) Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 17(12):7283-94
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41