DAS2/YDR020C Protein Information

Standard Name	Das2p 1, 2
Systematic Name	Ydr020cp
Alias	Rrt3p 2
ORF Classification	Uncharacterized
Description	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases (2, 3)
Name Description	Dst1-delta 6-Azauracil Sensitivity 1

Experimental Data
Molecules/cell	4280 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	232
Molecular Weight (Da)	26,595
Isoelectric Point (pI)	4.65

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Das2p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B6C5 \| Q12084 MIPS: YDR020C NCBI: 1216227 \| 1431448 \| 398365047 \| 45271032 \| 74676519 \| 840873 \| NP_010303.3 \| NM_001180328.3 GenBank/EMBL/DDBJ: DAA11866.1 \| AY558571 \| X95966 \| Z49770 \| Z74316
External Classifications	EC: 2.7.1.48 [Uridine kinase]

Amino Acid Sequence (or in FASTA format)
1 MDRKAVEEKR IVISIGGGHA TGVGAIALDL QNTFKSLYNS INIRVINLDN 51 MIEGNIKSYN NNDYDFDNIL NLVYEKHAVT SQNDMIQHDY EDPIDLIIVC 101 GCYALYDKRI NEISQLKVFL DSDADKRLIS LIKKKNVGSN EQLAQLITEY 151 MDHLRPEMQQ YIEPTRTFAD LIIPSTNENL GRAVLVDGIV KAIEDTKSQI 201 EGNNTNNKIR PRLWDFEAET MDLEKDRYYD LS*

Amino Acid Sequence (or in FASTA format)

       1  MDRKAVEEKR IVISIGGGHA TGVGAIALDL QNTFKSLYNS INIRVINLDN
      51  MIEGNIKSYN NNDYDFDNIL NLVYEKHAVT SQNDMIQHDY EDPIDLIIVC
     101  GCYALYDKRI NEISQLKVFL DSDADKRLIS LIKKKNVGSN EQLAQLITEY
     151  MDHLRPEMQQ YIEPTRTFAD LIIPSTNENL GRAVLVDGIV KAIEDTKSQI
     201  EGNNTNNKIR PRLWDFEAET MDLEKDRYYD LS*

external links for Das2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Das2p

1)	Chavez S (2007) personal communication
2)	Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
3)	Dardalhon M, et al. (2000) Disruption and functional analysis of six ORFs on chromosome IV: YDR013w, YDR014w, YDR015c, YDR018c, YDR020c, YDR021w (FAL1). Yeast 16(3):267-76
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41