SNQ2/YDR011W Protein Information Help

Standard Name Snq2p 1
Systematic Name Ydr011wp
ORF Classification Verified
Description Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species (2, 3, 4, 5, 6)
Name Description Sensitivity to 4-NitroQuinoline-N-oxide 1
Experimental Data
Molecules/cell 1300 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,501
Molecular Weight (Da) 168,765
Isoelectric Point (pI) 7.57

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Snq2p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004C4D6 | P32568
MIPS: YDR011W
NCBI: 1216218 | 1351079 | 1431430 | 295839 | 6320214 | 642816 | NP_010294.1
GenBank/EMBL/DDBJ: DAA11857.1 | X66732 | X95966 | Z48008 | Z74307
External Classifications TC: 3.A.1.205 [The Pleiotropic Drug Resistance (PDR) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MSNIKSTQDS SHNAVARSSS ASFAASEESF TGITHDKDEQ SDTPADKLTK
      51  MLTGPARDTA SQISATVSEM APDVVSKVES FADALSRHTT RSGAFNMDSD
     101  SDDGFDAHAI FESFVRDADE QGIHIRKAGV TIEDVSAKGV DASALEGATF
     151  GNILCLPLTI FKGIKAKRHQ KMRQIISNVN ALAEAGEMIL VLGRPGAGCS
     201  SFLKVTAGEI DQFAGGVSGE VAYDGIPQEE MMKRYKADVI YNGELDVHFP
     251  YLTVKQTLDF AIACKTPALR VNNVSKKEYI ASRRDLYATI FGLRHTYNTK
     301  VGNDFVRGVS GGERKRVSIA EALAAKGSIY CWDNATRGLD ASTALEYAKA
     351  IRIMTNLLKS TAFVTIYQAS ENIYETFDKV TVLYSGKQIY FGLIHEAKPY
     401  FAKMGYLCPP RQATAEFLTA LTDPNGFHLI KPGYENKVPR TAEEFETYWL
     451  NSPEFAQMKK DIAAYKEKVN TEKTKEVYDE SMAQEKSKYT RKKSYYTVSY
     501  WEQVKLCTQR GFQRIYGNKS YTVINVCSAI IQSFITGSLF YNTPSSTSGA
     551  FSRGGVLYFA LLYYSLMGLA NISFEHRPIL QKHKGYSLYH PSAEAIGSTL
     601  ASFPFRMIGL TCFFIILFFL SGLHRTAGSF FTIYLFLTMC SEAINGLFEM
     651  VSSVCDTLSQ ANSISGILMM SISMYSTYMI QLPSMHPWFK WISYVLPIRY
     701  AFESMLNAEF HGRHMDCANT LVPSGGDYDN LSDDYKVCAF VGSKPGQSYV
     751  LGDDYLKNQF QYVYKHTWRN FGILWCFLLG YVVLKVIFTE YKRPVKGGGD
     801  ALIFKKGSKR FIAHADEESP DNVNDIDAKE QFSSESSGAN DEVFDDLEAK
     851  GVFIWKDVCF TIPYEGGKRM LLDNVSGYCI PGTMTALMGE SGAGKTTLLN
     901  TLAQRNVGII TGDMLVNGRP IDASFERRTG YVQQQDIHIA ELTVRESLQF
     951  SARMRRPQHL PDSEKMDYVE KIIRVLGMEE YAEALVGEVG CGLNVEQRKK
    1001  LSIGVELVAK PDLLLFLDEP TSGLDSQSSW AIIQLLRKLS KAGQSILCTI
    1051  HQPSATLFEE FDRLLLLRKG GQTVYFGDIG KNSATILNYF ERNGARKCDS
    1101  SENPAEYILE AIGAGATASV KEDWHEKWLN SVEFEQTKEK VQDLINDLSK
    1151  QETKSEVGDK PSKYATSYAY QFRYVLIRTS TSFWRSLNYI MSKMMLMLVG
    1201  GLYIGFTFFN VGKSYVGLQN AMFAAFISII LSAPAMNQIQ GRAIASRELF
    1251  EVRESQSNMF HWSLVLITQY LSELPYHLFF STIFFVSSYF PLRIFFEASR
    1301  SAVYFLNYCI MFQLYYVGLG LMILYMSPNL PSANVILGLC LSFMLSFCGV
    1351  TQPVSLMPGF WTFMWKASPY TYFVQNLVGI MLHKKPVVCK KKELNYFNPP
    1401  NGSTCGEYMK PFLEKATGYI ENPDATSDCA YCIYEVGDNY LTHISSKYSY
    1451  LWRNFGIFWI YIFFNIIAMV CVYYLFHVRQ SSFLSPVSIL NKIKNIRKKK
    1501  Q*

external links for Snq2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome TCDB
YOGY GeneMANIA YeastRC Structure Prediction (Seattle)

YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Snq2p
1) Servos J, et al.  (1993) Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Mol Gen Genet 236(2-3):214-8
2) Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45
3) Rogers B, et al.  (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
4) Ververidis P, et al.  (2001) A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisiae. Curr Genet 39(3):127-36
5) Navarre C, et al.  (2002) Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae. Proteomics 2(12):1706-14
6) Anderson JB, et al.  (2003) Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 163(4):1287-98
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41