TRP1/YDR007W Protein Information

Standard Name	Trp1p 1
Systematic Name	Ydr007wp
ORF Classification	Verified
Description	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) (2)
Name Description	TRyPtophan requiring

Experimental Data
Molecules/cell	1850 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	224
Molecular Weight (Da)	24,144
Isoelectric Point (pI)	5.16

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Trp1p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000011EE00 \| P00912 MIPS: YDR007W NCBI: 1052971 \| 1326006 \| 173017 \| 173571 \| 398364971 \| 45719960 \| 45719962 \| 45719966 \| 56757555 \| 642812 \| NP_010290.3 GenBank/EMBL/DDBJ: DAA11855.1 \| AJ585667 \| AJ585668 \| AJ585669 \| AJ585670 \| AJ585671 \| AJ585672 \| AJ585673 \| AJ585674 \| AJ585675 \| AJ585676 \| AJ585677 \| AJ585678 \| AJ585679 \| AJ585680 \| AJ585681 \| AJ585682 \| AJ585683 \| AJ585684 \| AJ585685 \| M30386 \| M74015 \| U37458 \| V01341 \| Z48008
External Classifications	EC: 5.3.1.24 [Phosphoribosylanthranilate isomerase]

Amino Acid Sequence (or in FASTA format)
1 MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP 51 VIARKISSLV KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH 101 GDESWQEYQE FLGLPVIKRL VFPKDCNILL SAASQKPHSF IPLFDSEAGG 151 TGELLDWNSI SDWVGRQESP ESLHFMLAGG LTPENVGDAL RLNGVIGVDV 201 SGGVETNGVK DSNKIANFVK NAKK*

Amino Acid Sequence (or in FASTA format)

       1  MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP
      51  VIARKISSLV KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH
     101  GDESWQEYQE FLGLPVIKRL VFPKDCNILL SAASQKPHSF IPLFDSEAGG
     151  TGELLDWNSI SDWVGRQESP ESLHFMLAGG LTPENVGDAL RLNGVIGVDV
     201  SGGVETNGVK DSNKIANFVK NAKK*

external links for Trp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Trp1p

1)	Campbell, D. (1989) Personal Communication, Mortimer Map Edition 10
2)	Braus GH (1991) Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway. Microbiol Rev 55(3):349-70
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41