RAD57/YDR004W Protein Information

Standard Name	Rad57p
Systematic Name	Ydr004wp
ORF Classification	Verified
Description	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p (1, 2)
Name Description	RADiation sensitive

Experimental Data
Molecules/cell	238 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	460
Molecular Weight (Da)	52,247
Isoelectric Point (pI)	6.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rad57p (InterPro)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013303C \| P25301 MIPS: YDR004W NCBI: 131784 \| 172345 \| 6320207 \| 642809 \| NP_010287.1 GenBank/EMBL/DDBJ: DAA11852.1 \| M65061 \| Z48008

Amino Acid Sequence (or in FASTA format)
1 MPRALSIKFD NTYMDLYDEL PESKLLYDEE FSYLLDAVRQ NGVCVVDFLT 51 LTPKELARLI QRSINEVFRF QQLLVHEYNE KYLEICEKNS ISPDNGPECF 101 TTADVAMDEL LGGGIFTHGI TEIFGESSTG KSQLLMQLAL SVQLSEPAGG 151 LGGKCVYITT EGDLPTQRLE SMLSSRPAYE KLGITQSNIF TVSCNDLINQ 201 EHIINVQLPI LLERSKGSIK LVIIDSISHH LRVELQNKSF RESQENKNYL 251 DRMAEKLQIL AHDYSLSVVV ANQVGDKPLA NSPVAHRTYV TDYDYQLGWL 301 VGWKNSTILY RQMNSLLGAS SNNDEILSDD EDYMLIERVM STVNDRNYDF 351 FSKKKPPIIE NKTVERNSSS PISRQSKKRK FDYRVPNLGL TWSNHVSTRI 401 LLQKSFKAST IIQRGEAHLY KGGDSASFWQ VKRTMKVVYS TFAKPGQIAY 451 QITKRGIETA *

Amino Acid Sequence (or in FASTA format)

       1  MPRALSIKFD NTYMDLYDEL PESKLLYDEE FSYLLDAVRQ NGVCVVDFLT
      51  LTPKELARLI QRSINEVFRF QQLLVHEYNE KYLEICEKNS ISPDNGPECF
     101  TTADVAMDEL LGGGIFTHGI TEIFGESSTG KSQLLMQLAL SVQLSEPAGG
     151  LGGKCVYITT EGDLPTQRLE SMLSSRPAYE KLGITQSNIF TVSCNDLINQ
     201  EHIINVQLPI LLERSKGSIK LVIIDSISHH LRVELQNKSF RESQENKNYL
     251  DRMAEKLQIL AHDYSLSVVV ANQVGDKPLA NSPVAHRTYV TDYDYQLGWL
     301  VGWKNSTILY RQMNSLLGAS SNNDEILSDD EDYMLIERVM STVNDRNYDF
     351  FSKKKPPIIE NKTVERNSSS PISRQSKKRK FDYRVPNLGL TWSNHVSTRI
     401  LLQKSFKAST IIQRGEAHLY KGGDSASFWQ VKRTMKVVYS TFAKPGQIAY
     451  QITKRGIETA *

external links for Rad57p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rad57p

1)	Fortin GS and Symington LS (2002) Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes. EMBO J 21(12):3160-70
2)	Symington LS (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66(4):630-70, table of contents
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41