SHS1/YDL225W Protein Information 
| Standard Name | Shs1p 1 |
|---|---|
| Systematic Name | Ydl225wp |
| Alias | Sep7p 2 |
| ORF Classification | Verified |
| Description | Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress (1, 10, 11, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Seventh Homolog of Septin 1 |
| Experimental Data | |
|---|---|
| Molecules/cell | 5620 12 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Shs1p (InterPro) |
| Physical Interactions | There are 94 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000004F0AD | Q07657 MIPS: YDL225W NCBI: 1431379 | 2500772 | 6319976 | NP_010056.1 GenBank/EMBL/DDBJ: DAA11640.1 | Z74273 |
external links for Shs1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| Candida (CGD) | BioPIXIE | MIPS | YeastGFP |
| Candida (CandidaDB) | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| YGOB | Complexome | YeastRC Structure Prediction (Seattle) | |
| YOGY | DIP | ||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Shs1p
| 1) | Mino A, et al. (1998) Shs1p: a novel member of septin that interacts with spa2p, involved in polarized growth in saccharomyces cerevisiae. Biochem Biophys Res Commun 251(3):732-6 |
| 2) | Carroll CW, et al. (1998) The septins are required for the mitosis-specific activation of the Gin4 kinase. J Cell Biol 143(3):709-17 |
| 3) | Johnson ES and Blobel G (1999) Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins. J Cell Biol 147(5):981-94 |
| 4) | Takizawa PA, et al. (2000) Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290(5490):341-4 |
| 5) | Mortensen EM, et al. (2002) Cell cycle-dependent assembly of a Gin4-septin complex. Mol Biol Cell 13(6):2091-105 |
| 6) | Hanrahan J and Snyder M (2003) Cytoskeletal activation of a checkpoint kinase. Mol Cell 12(3):663-73 |
| 7) | Conde R, et al. (2003) Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins. Yeast 20(14):1189-211 |
| 8) | Versele M, et al. (2004) Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell 15(10):4568-83 |
| 9) | Vrabioiu AM, et al. (2004) The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem 279(4):3111-8 |
| 10) | McMurray MA, et al. (2011) Septin filament formation is essential in budding yeast. Dev Cell 20(4):540-9 |
| 11) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 12) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
