RTN2/YDL204W Protein Information

Standard Name	Rtn2p 1
Systematic Name	Ydl204wp
ORF Classification	Verified
Description	Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	ReTiculoN-like 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	393
Molecular Weight (Da)	44,359
Isoelectric Point (pI)	10.04

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rtn2p (InterPro)
Transmembrane Domains	There are 2 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A462 \| Q12443 MIPS: YDL204W NCBI: 1429353 \| 1431338 \| 32331689 \| 6319997 \| 74645057 \| NP_010077.1 GenBank/EMBL/DDBJ: DAA11660.1 \| AY164797 \| X99000 \| Z74252

Amino Acid Sequence (or in FASTA format)
1 MNRNTTTNKN ANLNNSRNAN APGEAGHQNK TGLIYWTNPS KSGASFAATL 51 VSLLILRNVN VISVLLKIGY MVLFTSFAVE LSTKVLFDKG VVSRFGMQES 101 PDLVGVLKPH IDRELDRLPA LEDRIRKLVF AHRTRNNFTI GVSLYFLHGL 151 FAIFSMNTVL IMTTIFLYTV PLIYDRKQAR IDRAIDRMKD LVIHRFHKNY 201 NKVVEKTEPY IDKIIPPQTD EGSYSTSISN ENKSSTSQRN KSGLSSSEFD 251 NMNDTSASKS GKDSYSTSQY NRAEYPVSQN ENIGTLKSGK QEIPTEKDFN 301 NRHENFSKPD VKTYDPRTVD IEEELAAHQR ELEQNLKDGD YNLVGSKEIP 351 DPITVPAPTR HTTKPAESQS IPIKNNETLH KTTHGLKQKL QHA*

Amino Acid Sequence (or in FASTA format)

       1  MNRNTTTNKN ANLNNSRNAN APGEAGHQNK TGLIYWTNPS KSGASFAATL
      51  VSLLILRNVN VISVLLKIGY MVLFTSFAVE LSTKVLFDKG VVSRFGMQES
     101  PDLVGVLKPH IDRELDRLPA LEDRIRKLVF AHRTRNNFTI GVSLYFLHGL
     151  FAIFSMNTVL IMTTIFLYTV PLIYDRKQAR IDRAIDRMKD LVIHRFHKNY
     201  NKVVEKTEPY IDKIIPPQTD EGSYSTSISN ENKSSTSQRN KSGLSSSEFD
     251  NMNDTSASKS GKDSYSTSQY NRAEYPVSQN ENIGTLKSGK QEIPTEKDFN
     301  NRHENFSKPD VKTYDPRTVD IEEELAAHQR ELEQNLKDGD YNLVGSKEIP
     351  DPITVPAPTR HTTKPAESQS IPIKNNETLH KTTHGLKQKL QHA*

external links for Rtn2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rtn2p

1)	Oertle T, et al. (2003) A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. FASEB J 17(10):1238-47
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Voeltz GK, et al. (2006) A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 124(3):573-86
4)	Suda Y, et al. (2007) Alternative Modes of Organellar Segregation during Sporulation in Saccharomyces cerevisiae. Eukaryot Cell 6(11):2009-17
5)	West M, et al. (2011) A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. J Cell Biol 193(2):333-46
6)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76