UGA3/YDL170W Protein Information Help

Standard Name Uga3p 1, 2
Systematic Name Ydl170wp
ORF Classification Verified
Description Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus (3, 4, 5)
Name Description Utilization of GAba 2
Experimental Data
Molecules/cell 1200 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 528
Molecular Weight (Da) 61,223
Isoelectric Point (pI) 6.68

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Uga3p (InterPro)
Physical Interactions There are 3 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000137AE8 | P26370
MIPS: YDL170W
NCBI: 1061269 | 136747 | 1431272 | 495234 | 6320031 | 854541 | NP_010111.1
GenBank/EMBL/DDBJ: DAA11691.1 | X51664 | X82846 | Z67750 | Z74218
Amino Acid Sequence (or in FASTA format)
 
       1  MNYGVEKLKL KYSKHGCITC KIRKKRCSED KPVCRDCRRL SFPCIYISES
      51  VDKQSLKKIK ADIQHQLISK KRKHAPDSAQ KAAVATRTRR VGSDEQDNQV
     101  YLSKPLEDCI SQKLDSMGLQ LYNYYRSHLA NIISIAPMNQ NYYLNIFLPM
     151  AHENDGILFA ILAWSANHLS ISSSNELRKD EIFVNLANKY TYMSLSHLKT
     201  NEGSSACAKL GFLYSLAQIL ILCGSEICQG DVKFWKILLN IGKNLIENHV
     251  GKDVSRILTT TTEEPSLEER IIFPNFNSVV KYWLIVNFIY HDILNFNTTS
     301  FPIEQYEKFF QRDQNSLPSS ANFIESIDSP IEEIDPLIGI NKPILLLLGQ
     351  VTNLTRFLQT MEQEEMLEHG DKILSLQVEI YKLQPSLMAL EHLDDEKKFY
     401  YLELFEIMKI STLMFFQLTL LKIDKDSLEL QILRNKLDSK LDKVIGTFLE
     451  GSLCFPLFIY GVCIQVEDME KKIDLEAKFD DILKRYKCYN FQNARLLIRK
     501  IWQNEADGIS EHDLVHMIDE LDYNINFA*

external links for Uga3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Uga3p
1) Andre B  (1990) The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. Mol Gen Genet 220(2):269-76
2) Ramos F, et al.  (1985) Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem 149(2):401-4
3) Talibi D, et al.  (1995) Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae. Nucleic Acids Res 23(4):550-7
4) Noel J and Turcotte B  (1998) Zinc cluster proteins Leu3p and Uga3p recognize highly related but distinct DNA targets. J Biol Chem 273(28):17463-8
5) Idicula AM, et al.  (2002) Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. J Biol Chem 277(48):45977-83
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41