FAP7/YDL166C Protein Information

Standard Name	Fap7p
Systematic Name	Ydl166cp
ORF Classification	Verified
Description	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D (1)
Name Description	Factor Activating Pos9 2

Experimental Data
Molecules/cell	8350 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	197
Molecular Weight (Da)	22,723
Isoelectric Point (pI)	4.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fap7p (InterPro)
Physical Interactions	There are 46 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531FC \| Q12055 MIPS: YDL166C NCBI: 1061273 \| 1431264 \| 45271026 \| 6320035 \| 6831740 \| NP_010115.1 GenBank/EMBL/DDBJ: DAA11695.1 \| AY558568 \| Z67750 \| Z74214
External Classifications	EC: 2.7.4.3 [Adenylate kinase]

Amino Acid Sequence (or in FASTA format)
1 MEARRYGPNI IVTGTPGCGK SSTCEFLKNK LKDYKYYNIS DFAKDNDCFE 51 GYDEGRKSHI VDEDKLLDML EPLLRQGNSI VDWHVNDVFP ERLIDLVVVL 101 RCDNSNLYSR LHARGYHDSK IEENLDAEIM GVVKQDAVES YEPHIVVELQ 151 SDTKEDMVSN VSRIVAWEKM WLEQHPDGVT NEYQGPRSDD EDDEDSE*

Amino Acid Sequence (or in FASTA format)

       1  MEARRYGPNI IVTGTPGCGK SSTCEFLKNK LKDYKYYNIS DFAKDNDCFE
      51  GYDEGRKSHI VDEDKLLDML EPLLRQGNSI VDWHVNDVFP ERLIDLVVVL
     101  RCDNSNLYSR LHARGYHDSK IEENLDAEIM GVVKQDAVES YEPHIVVELQ
     151  SDTKEDMVSN VSRIVAWEKM WLEQHPDGVT NEYQGPRSDD EDDEDSE*

external links for Fap7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Fap7p

1)	Granneman S, et al. (2005) The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14. Mol Cell Biol 25(23):10352-64
2)	Juhnke H, et al. (2000) The essential protein fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae. Mol Microbiol 35(4):936-48
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41